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Safety, Tolerability, and Pharmacokinetics of the Novel Hepatitis B Virus Expression Inhibitor GST-HG131 in Healthy Chinese Subjects: a First-in-Human Single- and Multiple-Dose Escalation Trial.
Li X, Liu Y, Yao H, Wang M, Gao L, Lou J, Mao J, Wu W, Zhou Y, Tang Y, Yan W, Hu Y, Ding C, Chen S, Niu J, Ding Y. Li X, et al. Among authors: chen s. Antimicrob Agents Chemother. 2022 May 17;66(5):e0009422. doi: 10.1128/aac.00094-22. Epub 2022 Apr 11. Antimicrob Agents Chemother. 2022. PMID: 35404074 Free PMC article. Clinical Trial.
Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073.
Sun Y, Liao X, Huang Z, Xie Y, Liu Y, Ma C, Jiang B, Zhang L, Yan Y, Li G, Cheng X, Yin Q, Ding CZ, Shen L, Li J, Chen S, Wei Y, Wang Z, Wei X. Sun Y, et al. Among authors: chen s. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00529-20. doi: 10.1128/AAC.00529-20. Print 2020 Sep 21. Antimicrob Agents Chemother. 2020. PMID: 32718961 Free PMC article.
Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD).
Lu J, Chan CC, Sun D, Hu G, He H, Li J, Dong J, Liu K, Shen L, Hu L, Gu Q, Chen S, Wang T, Gong T, Tang W, Li X, Zhu X, Zeng X, Zhu Y, Xia Y, Huang Y, Zhu Y, Liu Z, Ding CZ. Lu J, et al. Among authors: chen s. Bioorg Med Chem Lett. 2022 Jun 15;66:128734. doi: 10.1016/j.bmcl.2022.128734. Epub 2022 Apr 15. Bioorg Med Chem Lett. 2022. PMID: 35436589
Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection.
Hu Y, Sun F, Yuan Q, Du J, Hu L, Gu Z, Zhou Q, Du X, He S, Sun Y, Wang Q, Fan L, Wang L, Qin S, Chen S, Li J, Wu W, Mao J, Zhou Y, Zhou Q, Zhang G, Ding CZ. Hu Y, et al. Among authors: chen s. Bioorg Med Chem Lett. 2022 Nov 1;75:128977. doi: 10.1016/j.bmcl.2022.128977. Epub 2022 Sep 8. Bioorg Med Chem Lett. 2022. PMID: 36089112
Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor.
Xu Z, Liu Y, Song B, Ren B, Xu X, Lin R, Zhu X, Chen C, Yang S, Zhu Y, Jiang W, Li W, Xia Y, Hu L, Chen S, Chan CC, Li J, Zhang X, Yang L, Tian X, Ding CZ. Xu Z, et al. Among authors: chen c, chen s. Bioorg Med Chem Lett. 2024 Jul 15;107:129769. doi: 10.1016/j.bmcl.2024.129769. Epub 2024 Apr 24. Bioorg Med Chem Lett. 2024. PMID: 38670537
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