Sawyer TK - Search Results

1

Demonstration of a Common DPhe⁷ to DNal(2')⁷ Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides.

Gimenez LE, Noblin TA, Williams SY, Mullick Bagchi S, Ji RL, Tao YX, Jeppesen CB, Conde-Frieboes KW, Sawyer TK, Grieco P, Cone RD. Gimenez LE, et al. Among authors: sawyer tk. J Med Chem. 2022 Apr 28;65(8):5990-6000. doi: 10.1021/acs.jmedchem.1c01295. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35404053 Free PMC article.

2

Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.

Haskell-Luevano C, Hendrata S, North C, Sawyer TK, Hadley ME, Hruby VJ, Dickinson C, Gantz I. Haskell-Luevano C, et al. Among authors: sawyer tk. J Med Chem. 1997 Jul 4;40(14):2133-9. doi: 10.1021/jm960840h. J Med Chem. 1997. PMID: 9216831

3

Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology.

Garrigou M, Sauvagnat B, Duggal R, Boo N, Gopal P, Johnston JM, Partridge A, Sawyer T, Biswas K, Boyer N. Garrigou M, et al. J Med Chem. 2022 Jul 14;65(13):8961-8974. doi: 10.1021/acs.jmedchem.2c00154. Epub 2022 Jun 15. J Med Chem. 2022. PMID: 35707970 Free PMC article.

4

Design and structure-activity relationships of C-terminal cyclic neurotensin fragment analogues.

Sefler AM, He JX, Sawyer TK, Holub KE, Omecinsky DO, Reily MD, Thanabal V, Akunne HC, Cody WL. Sefler AM, et al. Among authors: sawyer tk. J Med Chem. 1995 Jan 20;38(2):249-57. doi: 10.1021/jm00002a006. J Med Chem. 1995. PMID: 7830267

5

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

Leonard DM, Shuler KR, Poulter CJ, Eaton SR, Sawyer TK, Hodges JC, Su TZ, Scholten JD, Gowan RC, Sebolt-Leopold JS, Doherty AM. Leonard DM, et al. Among authors: sawyer tk. J Med Chem. 1997 Jan 17;40(2):192-200. doi: 10.1021/jm960602m. J Med Chem. 1997. PMID: 9003517

6

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: sawyer tk. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

7

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.

Shahripour AB, Plummer MS, Lunney EA, Sawyer TK, Stankovic CJ, Connolly MK, Rubin JR, Walker NP, Brady KD, Allen HJ, Talanian RV, Wong WW, Humblet C. Shahripour AB, et al. Among authors: sawyer tk. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2779-82. doi: 10.1016/s0960-894x(01)00573-x. Bioorg Med Chem Lett. 2001. PMID: 11591522

8

Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site.

Smith CW, Saneii HH, Sawyer TK, Pals DT, Scahill TA, Kamdar BV, Lawson JA. Smith CW, et al. Among authors: sawyer tk. J Med Chem. 1988 Jul;31(7):1377-82. doi: 10.1021/jm00402a022. J Med Chem. 1988. PMID: 3290486

9

Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin.

Epps DE, Cheney J, Schostarez H, Sawyer TK, Prairie M, Krueger WC, Mandel F. Epps DE, et al. Among authors: sawyer tk. J Med Chem. 1990 Aug;33(8):2080-6. doi: 10.1021/jm00170a006. J Med Chem. 1990. PMID: 2197411

10

Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.

Plummer MS, Holland DR, Shahripour A, Lunney EA, Fergus JH, Marks JS, McConnell P, Mueller WT, Sawyer TK. Plummer MS, et al. Among authors: sawyer tk. J Med Chem. 1997 Nov 7;40(23):3719-25. doi: 10.1021/jm970402q. J Med Chem. 1997. PMID: 9371236

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