Cone RD - Search Results

1

Demonstration of a Common DPhe⁷ to DNal(2')⁷ Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides.

Gimenez LE, Noblin TA, Williams SY, Mullick Bagchi S, Ji RL, Tao YX, Jeppesen CB, Conde-Frieboes KW, Sawyer TK, Grieco P, Cone RD. Gimenez LE, et al. Among authors: cone rd. J Med Chem. 2022 Apr 28;65(8):5990-6000. doi: 10.1021/acs.jmedchem.1c01295. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35404053 Free PMC article.

2

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.

Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD. Hruby VJ, et al. Among authors: cone rd. J Med Chem. 1995 Sep 1;38(18):3454-61. doi: 10.1021/jm00018a005. J Med Chem. 1995. PMID: 7658432

3

Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn.

Haskell-Luevano C, Rosenquist A, Souers A, Khong KC, Ellman JA, Cone RD. Haskell-Luevano C, et al. Among authors: cone rd. J Med Chem. 1999 Oct 21;42(21):4380-7. doi: 10.1021/jm990190s. J Med Chem. 1999. PMID: 10543881

4

De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.

Han G, Haskell-Luevano C, Kendall L, Bonner G, Hadley ME, Cone RD, Hruby VJ. Han G, et al. Among authors: cone rd. J Med Chem. 2004 Mar 11;47(6):1514-26. doi: 10.1021/jm030452x. J Med Chem. 2004. PMID: 14998337

5

Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

Pantel J, Williams SY, Mi D, Sebag J, Corbin JD, Weaver CD, Cone RD. Pantel J, et al. Among authors: cone rd. Eur J Pharmacol. 2011 Jun 11;660(1):139-47. doi: 10.1016/j.ejphar.2011.01.031. Epub 2011 Feb 4. Eur J Pharmacol. 2011. PMID: 21296065 Free PMC article.

6

Development of an assay for high-throughput energy expenditure monitoring in the zebrafish.

Renquist BJ, Zhang C, Williams SY, Cone RD. Renquist BJ, et al. Among authors: cone rd. Zebrafish. 2013 Sep;10(3):343-52. doi: 10.1089/zeb.2012.0841. Epub 2013 May 25. Zebrafish. 2013. PMID: 23705823 Free PMC article.

7

60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH.

Anderson EJ, Çakir I, Carrington SJ, Cone RD, Ghamari-Langroudi M, Gillyard T, Gimenez LE, Litt MJ. Anderson EJ, et al. Among authors: cone rd. J Mol Endocrinol. 2016 May;56(4):T157-74. doi: 10.1530/JME-16-0014. Epub 2016 Mar 3. J Mol Endocrinol. 2016. PMID: 26939593 Free PMC article. Review.

8

Obesity-associated mutant melanocortin-4 receptors with normal Gα_s coupling frequently exhibit other discoverable pharmacological and biochemical defects.

Gillyard T, Fowler K, Williams SY, Cone RD. Gillyard T, et al. Among authors: cone rd. J Neuroendocrinol. 2019 Oct;31(10):e12795. doi: 10.1111/jne.12795. Epub 2019 Oct 15. J Neuroendocrinol. 2019. PMID: 31529534

9

Determination of the melanocortin-4 receptor structure identifies Ca²⁺ as a cofactor for ligand binding.

Yu J, Gimenez LE, Hernandez CC, Wu Y, Wein AH, Han GW, McClary K, Mittal SR, Burdsall K, Stauch B, Wu L, Stevens SN, Peisley A, Williams SY, Chen V, Millhauser GL, Zhao S, Cone RD, Stevens RC. Yu J, et al. Among authors: cone rd. Science. 2020 Apr 24;368(6489):428-433. doi: 10.1126/science.aaz8995. Science. 2020. PMID: 32327598 Free PMC article.

10

Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2.

Chen V, Bruno AE, Britt LL, Hernandez CC, Gimenez LE, Peisley A, Cone RD, Millhauser GL. Chen V, et al. Among authors: cone rd. J Biol Chem. 2020 Nov 27;295(48):16370-16379. doi: 10.1074/jbc.RA120.015482. Epub 2020 Sep 17. J Biol Chem. 2020. PMID: 32943551 Free PMC article.

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