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Structure-activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects.
Can J Physiol Pharmacol. 2022 Jun 1;100(6):521-533. doi: 10.1139/cjpp-2021-0729. Epub 2022 Apr 8.
Can J Physiol Pharmacol. 2022.
PMID: 35395172
Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)- New piperazine derivative with antianxiety and antidepressant-like effects: Putative role of serotonergic system.
da Silva DM, Sanz G, Vaz BG, de Carvalho FS, Lião LM, de Oliveira DR, Moreira LKDS, Cardoso CS, de Brito AF, da Silva DPB, da Rocha FF, Santana IGC, Galdino PM, Costa EA, Menegatti R.
da Silva DM, et al. Among authors: moreira lkds.
Biomed Pharmacother. 2018 Jul;103:546-552. doi: 10.1016/j.biopha.2018.04.077. Epub 2018 Apr 24.
Biomed Pharmacother. 2018.
PMID: 29677541
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Development of pyrazole derivatives in the management of inflammation.
Turones LC, Martins AN, Moreira LKDS, Fajemiroye JO, Costa EA.
Turones LC, et al. Among authors: moreira lkds.
Fundam Clin Pharmacol. 2021 Apr;35(2):217-234. doi: 10.1111/fcp.12629. Epub 2020 Nov 27.
Fundam Clin Pharmacol. 2021.
PMID: 33171533
Review.
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Potential antidepressant-like effect of piperazine derivative LQFM212 in mice: Role of monoaminergic pathway and brain-derived neurotrophic factor.
Moreira LKDS, de Brito AF, da Silva DM, Siqueira L, da Silva DPB, Cardoso CS, Florentino IF, de Carvalho PMG, Ghedini PC, Menegatti R, Costa EA.
Moreira LKDS, et al.
Behav Brain Res. 2021 Mar 5;401:113066. doi: 10.1016/j.bbr.2020.113066. Epub 2020 Dec 14.
Behav Brain Res. 2021.
PMID: 33333109
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Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice.
Moreira LKDS, Silva RR, da Silva DM, Mendes MAS, de Brito AF, de Carvalho FS, Sanz G, Rodrigues MF, da Silva ACG, Thomaz DV, de Oliveira V, Vaz BG, Lião LM, Valadares MC, Gil ES, Costa EA, Noël F, Menegatti R.
Moreira LKDS, et al.
Behav Brain Res. 2022 Jan 24;417:113582. doi: 10.1016/j.bbr.2021.113582. Epub 2021 Sep 15.
Behav Brain Res. 2022.
PMID: 34536431
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LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes.
Moreira LKDS, Turones LC, Campos HM, Nazareth AM, Thomaz DV, Gil ES, Ghedini PC, Rocha FFD, Menegatti R, Fajemiroye JO, Costa EA.
Moreira LKDS, et al.
Life Sci. 2023 Jan 1;312:121199. doi: 10.1016/j.lfs.2022.121199. Epub 2022 Nov 17.
Life Sci. 2023.
PMID: 36402170
Free article.
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Investigation of anti-inflammatory potential of 5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione compound.
Almeida DS, da Silva DPB, Moreira LKDS, Menegatti R, Lião LM, Sanz G, Vaz BG, Ghedini PC, Costa EA, Florentino IF.
Almeida DS, et al. Among authors: moreira lkds.
Eur J Pharmacol. 2020 Nov 5;886:173388. doi: 10.1016/j.ejphar.2020.173388. Epub 2020 Aug 5.
Eur J Pharmacol. 2020.
PMID: 32768504
Free article.
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