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Structure-activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects.
Santana IGC, Almeida LS, Moreira LKDS, de Carvalho FS, Menegatti R, da Rocha ALB, Mazurok TA, Vaz BG, Lião LM, Brito AF, Fajemiroye JO, Costa EA, de Carvalho PMG. Santana IGC, et al. Among authors: moreira lkds. Can J Physiol Pharmacol. 2022 Jun 1;100(6):521-533. doi: 10.1139/cjpp-2021-0729. Epub 2022 Apr 8. Can J Physiol Pharmacol. 2022. PMID: 35395172
Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)- New piperazine derivative with antianxiety and antidepressant-like effects: Putative role of serotonergic system.
da Silva DM, Sanz G, Vaz BG, de Carvalho FS, Lião LM, de Oliveira DR, Moreira LKDS, Cardoso CS, de Brito AF, da Silva DPB, da Rocha FF, Santana IGC, Galdino PM, Costa EA, Menegatti R. da Silva DM, et al. Among authors: moreira lkds. Biomed Pharmacother. 2018 Jul;103:546-552. doi: 10.1016/j.biopha.2018.04.077. Epub 2018 Apr 24. Biomed Pharmacother. 2018. PMID: 29677541
Development of pyrazole derivatives in the management of inflammation.
Turones LC, Martins AN, Moreira LKDS, Fajemiroye JO, Costa EA. Turones LC, et al. Among authors: moreira lkds. Fundam Clin Pharmacol. 2021 Apr;35(2):217-234. doi: 10.1111/fcp.12629. Epub 2020 Nov 27. Fundam Clin Pharmacol. 2021. PMID: 33171533 Review.
Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice.
Moreira LKDS, Silva RR, da Silva DM, Mendes MAS, de Brito AF, de Carvalho FS, Sanz G, Rodrigues MF, da Silva ACG, Thomaz DV, de Oliveira V, Vaz BG, Lião LM, Valadares MC, Gil ES, Costa EA, Noël F, Menegatti R. Moreira LKDS, et al. Behav Brain Res. 2022 Jan 24;417:113582. doi: 10.1016/j.bbr.2021.113582. Epub 2021 Sep 15. Behav Brain Res. 2022. PMID: 34536431