Aihara H - Search Results

1

4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.

He T, Edwards TC, Xie J, Aihara H, Geraghty RJ, Wang Z. He T, et al. Among authors: aihara h. J Med Chem. 2022 Apr 14;65(7):5830-5849. doi: 10.1021/acs.jmedchem.2c00203. Epub 2022 Apr 4. J Med Chem. 2022. PMID: 35377638 Free PMC article.

2

Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).

Kankanala J, Marchand C, Abdelmalak M, Aihara H, Pommier Y, Wang Z. Kankanala J, et al. Among authors: aihara h. J Med Chem. 2016 Mar 24;59(6):2734-46. doi: 10.1021/acs.jmedchem.5b01973. Epub 2016 Mar 7. J Med Chem. 2016. PMID: 26910725 Free PMC article.

3

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y. Marchand C, et al. Among authors: aihara h. ACS Chem Biol. 2016 Jul 15;11(7):1925-33. doi: 10.1021/acschembio.5b01047. Epub 2016 May 11. ACS Chem Biol. 2016. PMID: 27128689 Free PMC article.

4

New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).

Ribeiro CJA, Kankanala J, Shi K, Kurahashi K, Kiselev E, Ravji A, Pommier Y, Aihara H, Wang Z. Ribeiro CJA, et al. Among authors: aihara h. Eur J Pharm Sci. 2018 Jun 15;118:67-79. doi: 10.1016/j.ejps.2018.03.021. Epub 2018 Mar 21. Eur J Pharm Sci. 2018. PMID: 29574079 Free PMC article.

5

The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.

Bohl HO, Ieong P, Lee JK, Lee T, Kankanala J, Shi K, Demir Ö, Kurahashi K, Amaro RE, Wang Z, Aihara H. Bohl HO, et al. Among authors: aihara h. J Biol Chem. 2018 May 25;293(21):7969-7981. doi: 10.1074/jbc.RA118.002503. Epub 2018 Apr 6. J Biol Chem. 2018. PMID: 29626094 Free PMC article.

6

Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.

Ribeiro CJA, Kankanala J, Xie J, Williams J, Aihara H, Wang Z. Ribeiro CJA, et al. Among authors: aihara h. Bioorg Med Chem Lett. 2019 Jan 15;29(2):257-261. doi: 10.1016/j.bmcl.2018.11.044. Epub 2018 Nov 22. Bioorg Med Chem Lett. 2019. PMID: 30522956 Free PMC article.

7

Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.

Kankanala J, Ribeiro CJA, Kiselev E, Ravji A, Williams J, Xie J, Aihara H, Pommier Y, Wang Z. Kankanala J, et al. Among authors: aihara h. J Med Chem. 2019 May 9;62(9):4669-4682. doi: 10.1021/acs.jmedchem.9b00274. Epub 2019 Apr 30. J Med Chem. 2019. PMID: 30998359 Free PMC article.

8

4-Benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors.

Senaweera S, He T, Cui H, Aihara H, Wang Z. Senaweera S, et al. Among authors: aihara h. Med Chem Res. 2021 Feb;30(2):371-386. doi: 10.1007/s00044-020-02662-w. Epub 2020 Nov 19. Med Chem Res. 2021. PMID: 33776385 Free PMC article.

9

Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.

Wang L, Edwards TC, Sahani RL, Xie J, Aihara H, Geraghty RJ, Wang Z. Wang L, et al. Among authors: aihara h. Eur J Med Chem. 2021 Oct 15;222:113640. doi: 10.1016/j.ejmech.2021.113640. Epub 2021 Jun 12. Eur J Med Chem. 2021. PMID: 34147908 Free PMC article.

10

4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity.

Cui H, Carlson AS, Schleiff MA, Divakaran A, Johnson JA, Buchholz CR, Zahid H, Vail NR, Shi K, Aihara H, Harki DA, Miller GP, Topczewski JJ, Pomerantz WCK. Cui H, et al. Among authors: aihara h. J Med Chem. 2021 Jul 22;64(14):10497-10511. doi: 10.1021/acs.jmedchem.1c00933. Epub 2021 Jul 8. J Med Chem. 2021. PMID: 34236185 Free PMC article.

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