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α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA. Ghanem SS, et al. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353605 Free PMC article.
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Fayyad M, Erskine D, Majbour NK, Vaikath NN, Ghanem SS, Sudhakaran IP, Abdesselem H, Lamprokostopoulou A, Vekrellis K, Morris CM, Attems J, El-Agnaf OMA. Fayyad M, et al. Among authors: ghanem ss. Brain Pathol. 2020 Jul;30(4):831-843. doi: 10.1111/bpa.12845. Epub 2020 May 6. Brain Pathol. 2020. PMID: 32324926 Free PMC article.
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila I, Vaikath NN, Majbour NK, Erskine D, Sudhakaran IP, Gupta V, Ghanem SS, Islam Z, Emara MM, Abdesselem HB, Kolatkar PR, Achappa DK, Vinardell T, El-Agnaf OMA. Hmila I, et al. Among authors: ghanem ss. FEBS J. 2022 Aug;289(15):4657-4673. doi: 10.1111/febs.16376. Epub 2022 Feb 25. FEBS J. 2022. PMID: 35090199 Free PMC article.
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J; International DLB Genetics Consortium; Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D. Hatton C, et al. Among authors: ghanem ss. Brain. 2022 May 24;145(4):1257-1263. doi: 10.1093/brain/awac002. Brain. 2022. PMID: 34999780 Free PMC article.
Immune-related biomarkers for Parkinson's disease.
Abdi IY, Ghanem SS, El-Agnaf OM. Abdi IY, et al. Among authors: ghanem ss. Neurobiol Dis. 2022 Aug;170:105771. doi: 10.1016/j.nbd.2022.105771. Epub 2022 May 19. Neurobiol Dis. 2022. PMID: 35598675 Free article. Review.
29 results