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Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Primofiore G, Settimo FD, Taliani S, Marini AM, Novellino E, Greco G, Lavecchia A, Besnard F, Trincavelli L, Costa B, Martini C. Primofiore G, et al. Among authors: costa b. J Med Chem. 2001 Jul 5;44(14):2286-97. doi: 10.1021/jm010827j. J Med Chem. 2001. PMID: 11428922
PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells.
Chelli B, Rossi L, Da Pozzo E, Costa B, Spinetti F, Rechichi M, Salvetti A, Lena A, Simorini F, Vanacore R, Scatena F, Da Settimo F, Gremigni V, Martini C. Chelli B, et al. Among authors: costa b. Chembiochem. 2005 Jun;6(6):1082-8. doi: 10.1002/cbic.200400350. Chembiochem. 2005. PMID: 15883977
Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Da Settimo F, Simorini F, Taliani S, La Motta C, Marini AM, Salerno S, Bellandi M, Novellino E, Greco G, Cosimelli B, Da Pozzo E, Costa B, Simola N, Morelli M, Martini C. Da Settimo F, et al. Among authors: costa b. J Med Chem. 2008 Sep 25;51(18):5798-806. doi: 10.1021/jm8003224. Epub 2008 Aug 26. J Med Chem. 2008. PMID: 18729350
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
Taliani S, Cosimelli B, Da Settimo F, Marini AM, La Motta C, Simorini F, Salerno S, Novellino E, Greco G, Cosconati S, Marinelli L, Salvetti F, L'Abbate G, Trasciatti S, Montali M, Costa B, Martini C. Taliani S, et al. Among authors: costa b. J Med Chem. 2009 Jun 25;52(12):3723-34. doi: 10.1021/jm9001154. J Med Chem. 2009. PMID: 19469479
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E, Margarida Bernardo M, Fridman R, Da Settimo F, Martini C, Rossello A. Nuti E, et al. Among authors: costa b. Eur J Med Chem. 2011 Jul;46(7):2617-29. doi: 10.1016/j.ejmech.2011.03.033. Epub 2011 Apr 2. Eur J Med Chem. 2011. PMID: 21514700 Free PMC article.
1,530 results