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Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
J Am Chem Soc. 2022 Apr 6;144(13):5855-5863. doi: 10.1021/jacs.1c12106. Epub 2022 Mar 25.
J Am Chem Soc. 2022.
PMID: 35333525
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
McIntosh JA, Liu Z, Andresen BM, Marzijarani NS, Moore JC, Marshall NM, Borra-Garske M, Obligacion JV, Fier PS, Peng F, Forstater JH, Winston MS, An C, Chang W, Lim J, Huffman MA, Miller SP, Tsay FR, Altman MD, Lesburg CA, Steinhuebel D, Trotter BW, Cumming JN, Northrup A, Bu X, Mann BF, Biba M, Hiraga K, Murphy GS, Kolev JN, Makarewicz A, Pan W, Farasat I, Bade RS, Stone K, Duan D, Alvizo O, Adpressa D, Guetschow E, Hoyt E, Regalado EL, Castro S, Rivera N, Smith JP, Wang F, Crespo A, Verma D, Axnanda S, Dance ZEX, Devine PN, Tschaen D, Canada KA, Bulger PG, Sherry BD, Truppo MD, Ruck RT, Campeau LC, Bennett DJ, Humphrey GR, Campos KR, Maddess ML.
McIntosh JA, et al. Among authors: bade rs.
Nature. 2022 Mar;603(7901):439-444. doi: 10.1038/s41586-022-04422-9. Epub 2022 Mar 16.
Nature. 2022.
PMID: 35296845
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Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.
Fier PS, Xu Y, Poirier M, Brito G, Zheng M, Bade R, Sirota E, Stone K, Tan L, Humphrey GR, Chang D, Bothe J, Zhang Y, Bernardoni F, Castro S, Zompa MA, Taylor J, Sirk KM, Diaz-Santana A, Diribe I, Emerson KM, Krishnamurthi B, Zhao R, Ward M, Xiao C, Ouyand H, Zhan J, Morris WJ.
Fier PS, et al.
Org Process Res Dev. 2021 Dec 17;25(12):2806-2815. doi: 10.1021/acs.oprd.1c00400. Epub 2021 Dec 10.
Org Process Res Dev. 2021.
PMID: 35095257
Review.
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