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Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models.
Gough SM, Flanagan JJ, Teh J, Andreoli M, Rousseau E, Pannone M, Bookbinder M, Willard R, Davenport K, Bortolon E, Cadelina G, Gordon D, Pizzano J, Macaluso J, Soto L, Corradi J, Digianantonio K, Drulyte I, Morgan A, Quinn C, Békés M, Ferraro C, Chen X, Wang G, Dong H, Wang J, Langley DR, Houston J, Gedrich R, Taylor IC. Gough SM, et al. Among authors: taylor ic. Clin Cancer Res. 2024 May 31. doi: 10.1158/1078-0432.CCR-23-3465. Online ahead of print. Clin Cancer Res. 2024. PMID: 38819400
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Morsy MHA, Lilienthal I, Lord M, Merrien M, Wasik AM, Sureda-Gómez M, Amador V, Johansson HJ, Lehtiö J, Garcia-Torre B, Martin-Subero JI, Tsesmetzis N, Tao S, Schinazi RF, Kim B, Sorteberg AL, Wickström M, Sheppard D, Rassidakis GZ, Taylor IA, Christensson B, Campo E, Herold N, Sander B. Morsy MHA, et al. Among authors: taylor ia. Blood. 2024 Jan 18;143(19):1953-1964. doi: 10.1182/blood.2023022241/2210808/blood.2023022241.pdf. Blood. 2024. PMID: 38774451 Free PMC article.
Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC. Liang CC, et al. Among authors: taylor ia. Nature. 2024 May;629(8012):697-703. doi: 10.1038/s41586-024-07347-7. Epub 2024 Apr 24. Nature. 2024. PMID: 38658755 Free PMC article.
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Abdelrazak Morsy MH, Lilienthal I, Lord M, Merrien M, Wasik AM, Sureda-Gómez M, Amador V, Johansson HJ, Lehtiö J, Garcia-Torre B, Martin-Subero JI, Tsesmetzis N, Tao S, Schinazi RF, Kim B, Sorteberg AL, Wickström M, Sheppard D, Rassidakis GZ, Taylor IA, Christensson B, Campo E, Herold N, Sander B. Abdelrazak Morsy MH, et al. Among authors: taylor ia. Blood. 2024 May 9;143(19):1953-1964. doi: 10.1182/blood.2023022241. Blood. 2024. PMID: 38237141 Free PMC article.
1,239 results