Kluck RM - Search Results

1

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells.

Moujalled D, Southon AG, Saleh E, Brinkmann K, Ke F, Iliopoulos M, Cross RS, Jenkins MR, Nhu D, Wang Z, Shi MX, Kluck RM, Lessene G, Grabow S, Bush AI, Strasser A. Moujalled D, et al. Among authors: kluck rm. Cell Death Differ. 2022 Jul;29(7):1335-1348. doi: 10.1038/s41418-022-00977-2. Epub 2022 Mar 24. Cell Death Differ. 2022. PMID: 35332309 Free PMC article.

2

Bcl-xL does not inhibit the function of Apaf-1.

Newmeyer DD, Bossy-Wetzel E, Kluck RM, Wolf BB, Beere HM, Green DR. Newmeyer DD, et al. Among authors: kluck rm. Cell Death Differ. 2000 Apr;7(4):402-7. doi: 10.1038/sj.cdd.4400665. Cell Death Differ. 2000. PMID: 10773825

3

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: kluck rm. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

4

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM. Uren RT, et al. Among authors: kluck rm. J Cell Biol. 2007 Apr 23;177(2):277-87. doi: 10.1083/jcb.200606065. J Cell Biol. 2007. PMID: 17452531 Free PMC article.

5

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM. Dewson G, et al. Among authors: kluck rm. Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005. Mol Cell. 2008. PMID: 18471982 Free article.

6

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.

Dewson G, Kluck RM. Dewson G, et al. Among authors: kluck rm. J Cell Sci. 2009 Aug 15;122(Pt 16):2801-8. doi: 10.1242/jcs.038166. J Cell Sci. 2009. PMID: 19795525 Free PMC article.

7

Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

Dewson G, Ma S, Frederick P, Hockings C, Tan I, Kratina T, Kluck RM. Dewson G, et al. Among authors: kluck rm. Cell Death Differ. 2012 Apr;19(4):661-70. doi: 10.1038/cdd.2011.138. Epub 2011 Oct 21. Cell Death Differ. 2012. PMID: 22015607 Free PMC article.

8

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.

Ferrer PE, Frederick P, Gulbis JM, Dewson G, Kluck RM. Ferrer PE, et al. Among authors: kluck rm. PLoS One. 2012;7(3):e31510. doi: 10.1371/journal.pone.0031510. Epub 2012 Mar 19. PLoS One. 2012. PMID: 22442658 Free PMC article.

9

Bak apoptotic function is not directly regulated by phosphorylation.

Tran VH, Bartolo R, Westphal D, Alsop A, Dewson G, Kluck RM. Tran VH, et al. Among authors: kluck rm. Cell Death Dis. 2013 Jan 10;4(1):e452. doi: 10.1038/cddis.2012.191. Cell Death Dis. 2013. PMID: 23303126 Free PMC article.

10

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM. Czabotar PE, et al. Among authors: kluck rm. Cell. 2013 Jan 31;152(3):519-31. doi: 10.1016/j.cell.2012.12.031. Cell. 2013. PMID: 23374347 Free article.

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