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Activation of the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients with SARS-CoV-2 Infection Could Contribute to COVID-19 Hypofibrinolytic State and Disease Severity Prognosis.
Claesen K, Sim Y, Bracke A, De Bruyn M, De Hert E, Vliegen G, Hotterbeekx A, Vujkovic A, van Petersen L, De Winter FHR, Brosius I, Theunissen C, van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Kumar-Singh S, De Meester I, Hendriks D. Claesen K, et al. Among authors: vliegen g. J Clin Med. 2022 Mar 9;11(6):1494. doi: 10.3390/jcm11061494. J Clin Med. 2022. PMID: 35329820 Free PMC article.
Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients.
Bracke A, De Hert E, De Bruyn M, Claesen K, Vliegen G, Vujkovic A, van Petersen L, De Winter FHR, Hotterbeekx A, Brosius I, Theunissen C, Van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Van der Veken P, Hendriks D, Kumar-Singh S, De Meester I. Bracke A, et al. Among authors: vliegen g. Clin Chim Acta. 2022 Jun 1;531:4-11. doi: 10.1016/j.cca.2022.03.005. Epub 2022 Mar 10. Clin Chim Acta. 2022. PMID: 35283094 Free PMC article.
CD26/DPP4 - a potential biomarker and target for cancer therapy.
Enz N, Vliegen G, De Meester I, Jungraithmayr W. Enz N, et al. Among authors: vliegen g. Pharmacol Ther. 2019 Jun;198:135-159. doi: 10.1016/j.pharmthera.2019.02.015. Epub 2019 Feb 26. Pharmacol Ther. 2019. PMID: 30822465 Review.
Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP).
De Decker A, Vliegen G, Van Rompaey D, Peeraer A, Bracke A, Verckist L, Jansen K, Geiss-Friedlander R, Augustyns K, De Winter H, De Meester I, Lambeir AM, Van der Veken P. De Decker A, et al. Among authors: vliegen g. ACS Med Chem Lett. 2019 Jul 9;10(8):1173-1179. doi: 10.1021/acsmedchemlett.9b00191. eCollection 2019 Aug 8. ACS Med Chem Lett. 2019. PMID: 31413802 Free PMC article.
Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators.
Moon ES, Elvas F, Vliegen G, De Lombaerde S, Vangestel C, De Bruycker S, Bracke A, Eppard E, Greifenstein L, Klasen B, Kramer V, Staelens S, De Meester I, Van der Veken P, Rösch F. Moon ES, et al. Among authors: vliegen g. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. doi: 10.1186/s41181-020-00102-z. EJNMMI Radiopharm Chem. 2020. PMID: 32728930 Free PMC article.
DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages.
de Vasconcelos NM, Vliegen G, Gonçalves A, De Hert E, Martín-Pérez R, Van Opdenbosch N, Jallapally A, Geiss-Friedlander R, Lambeir AM, Augustyns K, Van Der Veken P, De Meester I, Lamkanfi M. de Vasconcelos NM, et al. Among authors: vliegen g. Life Sci Alliance. 2019 Feb 4;2(1):e201900313. doi: 10.26508/lsa.201900313. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30718379 Free PMC article.
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