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Activation of the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients with SARS-CoV-2 Infection Could Contribute to COVID-19 Hypofibrinolytic State and Disease Severity Prognosis.
Claesen K, Sim Y, Bracke A, De Bruyn M, De Hert E, Vliegen G, Hotterbeekx A, Vujkovic A, van Petersen L, De Winter FHR, Brosius I, Theunissen C, van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Kumar-Singh S, De Meester I, Hendriks D. Claesen K, et al. Among authors: de winter fhr, de bruyn m, de hert e, de meester i. J Clin Med. 2022 Mar 9;11(6):1494. doi: 10.3390/jcm11061494. J Clin Med. 2022. PMID: 35329820 Free PMC article.
Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome.
Ceuleers H, Hanning N, Heirbaut J, Van Remoortel S, Joossens J, Van Der Veken P, Francque SM, De Bruyn M, Lambeir AM, De Man JG, Timmermans JP, Augustyns K, De Meester I, De Winter BY. Ceuleers H, et al. Among authors: de man jg, de bruyn m, de winter by, de meester i. Br J Pharmacol. 2018 Sep;175(17):3516-3533. doi: 10.1111/bph.14396. Epub 2018 Jul 23. Br J Pharmacol. 2018. PMID: 29911328 Free PMC article.
Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats.
Hanning N, De Bruyn M, Ceuleers H, Boogaerts T, Berg M, Smet A, De Schepper HU, Joossens J, van Nuijs ALN, De Man JG, Augustyns K, De Meester I, De Winter BY. Hanning N, et al. Among authors: de man jg, de bruyn m, de schepper hu, de winter by, de meester i. Pharmaceutics. 2021 May 29;13(6):811. doi: 10.3390/pharmaceutics13060811. Pharmaceutics. 2021. PMID: 34072320 Free PMC article.
Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients.
Bracke A, De Hert E, De Bruyn M, Claesen K, Vliegen G, Vujkovic A, van Petersen L, De Winter FHR, Hotterbeekx A, Brosius I, Theunissen C, Van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Van der Veken P, Hendriks D, Kumar-Singh S, De Meester I. Bracke A, et al. Among authors: de winter fhr, de bruyn m, de hert e, de meester i. Clin Chim Acta. 2022 Jun 1;531:4-11. doi: 10.1016/j.cca.2022.03.005. Epub 2022 Mar 10. Clin Chim Acta. 2022. PMID: 35283094 Free PMC article.
The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult.
Ceuleers H, Hanning N, De Bruyn M, De Man JG, De Schepper HU, Li Q, Liu L, Abrams S, Smet A, Joossens J, Augustyns K, De Meester I, Pasricha PJ, De Winter BY. Ceuleers H, et al. Among authors: de man jg, de bruyn m, de schepper hu, de winter by, de meester i. Front Pharmacol. 2022 Jun 2;13:765744. doi: 10.3389/fphar.2022.765744. eCollection 2022. Front Pharmacol. 2022. PMID: 35721192 Free PMC article.
Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases.
Ramos-Llorca A, Decraecker L, Cacheux VMY, Zeiburlina I, De Bruyn M, Battut L, Moreno-Cinos C, Ceradini D, Espinosa E, Dietrich G, Berg M, De Meester I, Van Der Veken P, Boeckxstaens G, Lambeir AM, Denadai-Souza A, Augustyns K. Ramos-Llorca A, et al. Among authors: de bruyn m, de meester i. Front Chem. 2023 Jan 5;10:1089959. doi: 10.3389/fchem.2022.1089959. eCollection 2022. Front Chem. 2023. PMID: 36688031 Free PMC article.
Prediction of recurrence risk in endometrial cancer with multimodal deep learning.
Volinsky-Fremond S, Horeweg N, Andani S, Barkey Wolf J, Lafarge MW, de Kroon CD, Ørtoft G, Høgdall E, Dijkstra J, Jobsen JJ, Lutgens LCHW, Powell ME, Mileshkin LR, Mackay H, Leary A, Katsaros D, Nijman HW, de Boer SM, Nout RA, de Bruyn M, Church D, Smit VTHBM, Creutzberg CL, Koelzer VH, Bosse T. Volinsky-Fremond S, et al. Among authors: de bruyn m. Nat Med. 2024 May 24. doi: 10.1038/s41591-024-02993-w. Online ahead of print. Nat Med. 2024. PMID: 38789645
183 results