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Activation of the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients with SARS-CoV-2 Infection Could Contribute to COVID-19 Hypofibrinolytic State and Disease Severity Prognosis.
Claesen K, Sim Y, Bracke A, De Bruyn M, De Hert E, Vliegen G, Hotterbeekx A, Vujkovic A, van Petersen L, De Winter FHR, Brosius I, Theunissen C, van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Kumar-Singh S, De Meester I, Hendriks D. Claesen K, et al. Among authors: bracke a. J Clin Med. 2022 Mar 9;11(6):1494. doi: 10.3390/jcm11061494. J Clin Med. 2022. PMID: 35329820 Free PMC article.
Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients.
Bracke A, De Hert E, De Bruyn M, Claesen K, Vliegen G, Vujkovic A, van Petersen L, De Winter FHR, Hotterbeekx A, Brosius I, Theunissen C, Van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Van der Veken P, Hendriks D, Kumar-Singh S, De Meester I. Bracke A, et al. Clin Chim Acta. 2022 Jun 1;531:4-11. doi: 10.1016/j.cca.2022.03.005. Epub 2022 Mar 10. Clin Chim Acta. 2022. PMID: 35283094 Free PMC article.
Dysregulated activities of proline-specific enzymes in septic shock patients (sepsis-2).
Vliegen G, Kehoe K, Bracke A, De Hert E, Verkerk R, Fransen E, Jongers B', Peters E, Lambeir AM, Kumar-Singh S, Pickkers P, Jorens PG, De Meester I. Vliegen G, et al. Among authors: bracke a. PLoS One. 2020 Apr 21;15(4):e0231555. doi: 10.1371/journal.pone.0231555. eCollection 2020. PLoS One. 2020. PMID: 32315321 Free PMC article.
Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP).
De Decker A, Vliegen G, Van Rompaey D, Peeraer A, Bracke A, Verckist L, Jansen K, Geiss-Friedlander R, Augustyns K, De Winter H, De Meester I, Lambeir AM, Van der Veken P. De Decker A, et al. Among authors: bracke a. ACS Med Chem Lett. 2019 Jul 9;10(8):1173-1179. doi: 10.1021/acsmedchemlett.9b00191. eCollection 2019 Aug 8. ACS Med Chem Lett. 2019. PMID: 31413802 Free PMC article.
Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators.
Moon ES, Elvas F, Vliegen G, De Lombaerde S, Vangestel C, De Bruycker S, Bracke A, Eppard E, Greifenstein L, Klasen B, Kramer V, Staelens S, De Meester I, Van der Veken P, Rösch F. Moon ES, et al. Among authors: bracke a. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. doi: 10.1186/s41181-020-00102-z. EJNMMI Radiopharm Chem. 2020. PMID: 32728930 Free PMC article.
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