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A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions.
Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, Liu H, Ding S, Hurd YL, Pasternak GW, Klein RJ, Cartegni L, Zhou W, Pan YX. Xu J, et al. Among authors: cartegni l. J Neurosci. 2014 Aug 13;34(33):11048-66. doi: 10.1523/JNEUROSCI.3986-13.2014. J Neurosci. 2014. PMID: 25122903 Free PMC article.
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.
Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC, Martínez-Rivera A, Rajadhyaksha AM, Cartegni L, Bassoni DL, Pasternak GW, Pan YX. Xu J, et al. Among authors: cartegni l. J Clin Invest. 2017 Apr 3;127(4):1561-1573. doi: 10.1172/JCI88760. Epub 2017 Mar 20. J Clin Invest. 2017. PMID: 28319053 Free PMC article.
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.
Lefave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L. Lefave CV, et al. Among authors: cartegni l. EMBO J. 2011 Sep 13;30(19):4084-97. doi: 10.1038/emboj.2011.259. EMBO J. 2011. PMID: 21915099 Free PMC article.
39 results