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2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner.
Belardinelli JM, Li W, Martin KH, Zeiler MJ, Lian E, Avanzi C, Wiersma CJ, Nguyen TV, Angala B, de Moura VCN, Jones V, Borlee BR, Melander C, Jackson M. Belardinelli JM, et al. Among authors: nguyen tv. Int J Mol Sci. 2022 Mar 9;23(6):2950. doi: 10.3390/ijms23062950. Int J Mol Sci. 2022. PMID: 35328372 Free PMC article.
2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.
Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ. Jeon AB, et al. Among authors: nguyen tv. PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017. PLoS One. 2017. PMID: 28749949 Free PMC article.
The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.
Nguyen TV, Blackledge MS, Lindsey EA, Minrovic BM, Ackart DF, Jeon AB, Obregón-Henao A, Melander RJ, Basaraba RJ, Melander C. Nguyen TV, et al. Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3940-3944. doi: 10.1002/anie.201612006. Epub 2017 Mar 1. Angew Chem Int Ed Engl. 2017. PMID: 28247991 Free PMC article.
Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria.
Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C. Barker WT, et al. Among authors: nguyen tv. Bioorg Med Chem. 2017 Oct 15;25(20):5749-5753. doi: 10.1016/j.bmc.2017.08.055. Epub 2017 Sep 9. Bioorg Med Chem. 2017. PMID: 28958847 Free PMC article.
1,361 results