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Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
M Serafim RA, da Silva Santiago A, Schwalm MP, Hu Z, Dos Reis CV, Takarada JE, Mezzomo P, Massirer KB, Kudolo M, Gerstenecker S, Chaikuad A, Zender L, Knapp S, Laufer S, Couñago RM, Gehringer M. M Serafim RA, et al. Among authors: zender l. J Med Chem. 2022 Feb 24;65(4):3173-3192. doi: 10.1021/acs.jmedchem.1c01165. Epub 2022 Feb 15. J Med Chem. 2022. PMID: 35167750
Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer.
Abdelmalek CM, Hu Z, Kronenberger T, Küblbeck J, Kinnen FJM, Hesse SS, Malik A, Kudolo M, Niess R, Gehringer M, Zender L, Witt-Enderby PA, Zlotos DP, Laufer SA. Abdelmalek CM, et al. Among authors: zender l. J Med Chem. 2022 Mar 24;65(6):4616-4632. doi: 10.1021/acs.jmedchem.1c01646. Epub 2022 Mar 14. J Med Chem. 2022. PMID: 35286086
Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Wentsch HK, Walter NM, Bührmann M, Mayer-Wrangowski S, Rauh D, Zaman GJR, Willemsen-Seegers N, Buijsman RC, Henning M, Dauch D, Zender L, Laufer S. Wentsch HK, et al. Among authors: zender l. Angew Chem Int Ed Engl. 2017 May 2;56(19):5363-5367. doi: 10.1002/anie.201701185. Epub 2017 Apr 11. Angew Chem Int Ed Engl. 2017. PMID: 28397331
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D'Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D. Rudalska R, et al. Among authors: zender l. Nat Cancer. 2021 Feb;2(2):201-217. doi: 10.1038/s43018-020-00168-3. Epub 2021 Feb 15. Nat Cancer. 2021. PMID: 35122079
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.
Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, Eilers M, Sipos B, Lowe SW, Geffers R, Laufer S, Zender L. Rudalska R, et al. Among authors: zender l. Nat Med. 2014 Oct;20(10):1138-46. doi: 10.1038/nm.3679. Epub 2014 Sep 14. Nat Med. 2014. PMID: 25216638 Free PMC article.
184 results