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AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.
Gathercole LL, Nikolaou N, Harris SE, Arvaniti A, Poolman TM, Hazlehurst JM, Kratschmar DV, Todorčević M, Moolla A, Dempster N, Pink RC, Saikali MF, Bentley L, Penning TM, Ohlsson C, Cummins CL, Poutanen M, Odermatt A, Cox RD, Tomlinson JW. Gathercole LL, et al. J Endocrinol. 2022 Apr 13;253(3):97-113. doi: 10.1530/JOE-21-0280. J Endocrinol. 2022. PMID: 35318963 Free PMC article.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: gathercole ll. Metabolism. 2019 Oct;99:67-80. doi: 10.1016/j.metabol.2019.153947. Epub 2019 Jul 19. Metabolism. 2019. PMID: 31330134 Free PMC article.
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.
Nikolaou N, Arvaniti A, Appanna N, Sharp A, Hughes BA, Digweed D, Whitaker MJ, Ross R, Arlt W, Penning TM, Morris K, George S, Keevil BG, Hodson L, Gathercole LL, Tomlinson JW. Nikolaou N, et al. Among authors: gathercole ll. J Endocrinol. 2020 May;245(2):207-218. doi: 10.1530/JOE-19-0473. J Endocrinol. 2020. PMID: 32106090 Free PMC article.
The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Harris SE, Poolman TM, Arvaniti A, Cox RD, Gathercole LL, Tomlinson JW. Harris SE, et al. Among authors: gathercole ll. Am J Physiol Gastrointest Liver Physiol. 2020 Sep 1;319(3):G345-G360. doi: 10.1152/ajpgi.00055.2020. Epub 2020 Aug 5. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32755310 Free PMC article.
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants.
Appanna N, Gibson H, Gangitano E, Dempster NJ, Morris K, George S, Arvaniti A, Gathercole LL, Keevil B, Penning TM, Storbeck KH, Tomlinson JW, Nikolaou N. Appanna N, et al. Among authors: gathercole ll. J Mol Endocrinol. 2021 Mar;66(3):181-194. doi: 10.1530/JME-20-0160. J Mol Endocrinol. 2021. PMID: 33502336 Free PMC article.
Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
Lavery GG, Zielinska AE, Gathercole LL, Hughes B, Semjonous N, Guest P, Saqib K, Sherlock M, Reynolds G, Morgan SA, Tomlinson JW, Walker EA, Rabbitt EH, Stewart PM. Lavery GG, et al. Among authors: gathercole ll. Endocrinology. 2012 Jul;153(7):3236-48. doi: 10.1210/en.2012-1019. Epub 2012 May 3. Endocrinology. 2012. PMID: 22555437 Free PMC article.
Hormonal regulation of lipogenesis.
Gathercole LL, Morgan SA, Tomlinson JW. Gathercole LL, et al. Vitam Horm. 2013;91:1-27. doi: 10.1016/B978-0-12-407766-9.00001-8. Vitam Horm. 2013. PMID: 23374710 Review.
37 results