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Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing.
Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2117770119. doi: 10.1073/pnas.2117770119. Epub 2022 Mar 21.
Proc Natl Acad Sci U S A. 2022.
PMID: 35312359
Free PMC article.
Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s.
Garrigues RJ, Thomas S, Leong JM, Garcia BL.
Garrigues RJ, et al.
J Biol Chem. 2022 Nov;298(11):102557. doi: 10.1016/j.jbc.2022.102557. Epub 2022 Sep 29.
J Biol Chem. 2022.
PMID: 36183830
Free PMC article.
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Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes.
Xie J, Zhi H, Garrigues RJ, Keightley A, Garcia BL, Skare JT.
Xie J, et al. Among authors: garrigues rj.
PLoS Pathog. 2019 Mar 21;15(3):e1007659. doi: 10.1371/journal.ppat.1007659. eCollection 2019 Mar.
PLoS Pathog. 2019.
PMID: 30897158
Free PMC article.
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A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes.
Garrigues RJ, Powell-Pierce AD, Hammel M, Skare JT, Garcia BL.
Garrigues RJ, et al.
J Immunol. 2021 Dec 1;207(11):2856-2867. doi: 10.4049/jimmunol.2100815. Epub 2021 Nov 10.
J Immunol. 2021.
PMID: 34759015
Free PMC article.
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Investigating the roles of the conserved Cu2+-binding residues on Brucella FtrA in producing conformational stability and functionality.
Banerjee S, Garrigues RJ, Chanakira MN, Negron-Olivo JJ, Odeh YH, Spuches AM, Martin Roop R 2nd, Pitzer JE, Martin DW, Dasgupta S.
Banerjee S, et al. Among authors: garrigues rj.
J Inorg Biochem. 2020 Sep;210:111162. doi: 10.1016/j.jinorgbio.2020.111162. Epub 2020 Jun 23.
J Inorg Biochem. 2020.
PMID: 32623149
Free PMC article.
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