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Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Nav 1.2 expression.
Eaton M, Zhang J, Ma Z, Park AC, Lietzke E, Romero CM, Liu Y, Coleman ER, Chen X, Xiao T, Que Z, Lai S, Wu J, Lee JH, Palant S, Nguyen HP, Huang Z, Skarnes WC, Koss WA, Yang Y. Eaton M, et al. Among authors: chen x. Genes Brain Behav. 2021 Apr;20(4):e12725. doi: 10.1111/gbb.12725. Epub 2021 Jan 18. Genes Brain Behav. 2021. PMID: 33369088 Free article.
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant.
Que Z, Olivero-Acosta MI, Zhang J, Eaton M, Tukker AM, Chen X, Wu J, Xie J, Xiao T, Wettschurack K, Yunis L, Shafer JM, Schaber JA, Rochet JC, Bowman AB, Yuan C, Huang Z, Hu CD, Trader DJ, Skarnes WC, Yang Y. Que Z, et al. Among authors: chen x. J Neurosci. 2021 Dec 8;41(49):10194-10208. doi: 10.1523/JNEUROSCI.0564-21.2021. Epub 2021 Oct 29. J Neurosci. 2021. PMID: 34716231 Free PMC article.
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.
Yang Y, Wu J, Zhang J, Chen X, Que Z, Wettschurack K, Deming B, Acosta M, Cui N, Eaton M, Zhao Y, Halurkar M, Purba M, Chen I, Xiao T, Suzuki M, Yuan C, Xu R, Koss W, Du D, Chen F, Wu LJ, Clinic M. Yang Y, et al. Among authors: chen f, chen x, chen i. Res Sq [Preprint]. 2023 Sep 28:rs.3.rs-3270664. doi: 10.21203/rs.3.rs-3270664/v1. Res Sq. 2023. PMID: 37841865 Free PMC article. Updated. Preprint.
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.
Que Z, Olivero-Acosta MI, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher CM, Wang M, Harlow H, Cui N, Chen X, Deming B, Halurkar M, Zhao Y, Rochet JC, Xu R, Brewster AL, Wu LJ, Yuan C, Skarnes WC, Yang Y. Que Z, et al. Among authors: chen x, chen i. bioRxiv [Preprint]. 2023 Oct 31:2023.10.26.563426. doi: 10.1101/2023.10.26.563426. bioRxiv. 2023. PMID: 37961213 Free PMC article. Preprint.
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