Liu D - Search Results

1

Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.

Zhu W, Butrin A, Melani RD, Doubleday PF, Ferreira GM, Tavares MT, Habeeb Mohammad TS, Beaupre BA, Kelleher NL, Moran GR, Liu D, Silverman RB. Zhu W, et al. Among authors: liu d. J Am Chem Soc. 2022 Mar 30;144(12):5629-5642. doi: 10.1021/jacs.2c00924. Epub 2022 Mar 16. J Am Chem Soc. 2022. PMID: 35293728 Free PMC article.

2

Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".

Liu D, Pozharski E, Lepore BW, Fu M, Silverman RB, Petsko GA, Ringe D. Liu D, et al. Biochemistry. 2007 Sep 18;46(37):10517-27. doi: 10.1021/bi700663n. Epub 2007 Aug 22. Biochemistry. 2007. PMID: 17713924

3

Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.

Lepore BW, Liu D, Peng Y, Fu M, Yasuda C, Manning JM, Silverman RB, Ringe D. Lepore BW, et al. Among authors: liu d. Biochemistry. 2010 Apr 13;49(14):3138-47. doi: 10.1021/bi902052x. Biochemistry. 2010. PMID: 20192272

4

Mechanism of inactivation of Escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid.

Liu D, Pozharski E, Fu M, Silverman RB, Ringe D. Liu D, et al. Biochemistry. 2010 Dec 14;49(49):10507-15. doi: 10.1021/bi101325z. Epub 2010 Nov 15. Biochemistry. 2010. PMID: 21033689 Free PMC article.

5

Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).

Lee H, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB. Lee H, et al. Among authors: liu d. J Am Chem Soc. 2015 Feb 25;137(7):2628-40. doi: 10.1021/ja512299n. Epub 2015 Feb 10. J Am Chem Soc. 2015. PMID: 25616005 Free PMC article.

6

Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators.

Le HV, Hawker DD, Wu R, Doud E, Widom J, Sanishvili R, Liu D, Kelleher NL, Silverman RB. Le HV, et al. Among authors: liu d. J Am Chem Soc. 2015 Apr 8;137(13):4525-33. doi: 10.1021/jacs.5b01155. Epub 2015 Mar 30. J Am Chem Soc. 2015. PMID: 25781189 Free PMC article.

7

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid.

Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB. Lee H, et al. Among authors: liu d. ACS Chem Biol. 2015 Sep 18;10(9):2087-98. doi: 10.1021/acschembio.5b00212. Epub 2015 Jul 6. ACS Chem Biol. 2015. PMID: 26110556 Free PMC article.

8

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ.

Clevenger KD, Mascarenhas R, Catlin D, Wu R, Kelleher NL, Drake EJ, Gulick AM, Liu D, Fast W. Clevenger KD, et al. Among authors: liu d. ACS Chem Biol. 2017 Mar 17;12(3):643-647. doi: 10.1021/acschembio.7b00031. Epub 2017 Feb 15. ACS Chem Biol. 2017. PMID: 28186406 Free PMC article.

9

PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.

Wu R, Sanishvili R, Belitsky BR, Juncosa JI, Le HV, Lehrer HJ, Farley M, Silverman RB, Petsko GA, Ringe D, Liu D. Wu R, et al. Among authors: liu d. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3891-3896. doi: 10.1073/pnas.1703019114. Epub 2017 Mar 27. Proc Natl Acad Sci U S A. 2017. PMID: 28348215 Free PMC article.

10

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.

Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Mascarenhas R, et al. Among authors: liu d. Biochemistry. 2017 Sep 19;56(37):4951-4961. doi: 10.1021/acs.biochem.7b00499. Epub 2017 Sep 6. Biochemistry. 2017. PMID: 28816437 Free PMC article.

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