Forbes BE - Search Results

1

Symmetric and asymmetric receptor conformation continuum induced by a new insulin.

Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH. Xiong X, et al. Among authors: forbes be. Nat Chem Biol. 2022 May;18(5):511-519. doi: 10.1038/s41589-022-00981-0. Epub 2022 Mar 14. Nat Chem Biol. 2022. PMID: 35289328 Free PMC article.

2

A novel binding site for the human insulin-like growth factor-II (IGF-II)/mannose 6-phosphate receptor on IGF-II.

Delaine C, Alvino CL, McNeil KA, Mulhern TD, Gauguin L, De Meyts P, Jones EY, Brown J, Wallace JC, Forbes BE. Delaine C, et al. Among authors: forbes be. J Biol Chem. 2007 Jun 29;282(26):18886-94. doi: 10.1074/jbc.M700531200. Epub 2007 May 2. J Biol Chem. 2007. PMID: 17475626 Free article.

3

Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I.

Gauguin L, Delaine C, Alvino CL, McNeil KA, Wallace JC, Forbes BE, De Meyts P. Gauguin L, et al. Among authors: forbes be. J Biol Chem. 2008 Jul 25;283(30):20821-9. doi: 10.1074/jbc.M802620200. Epub 2008 May 23. J Biol Chem. 2008. PMID: 18502759 Free PMC article.

4

A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.

Alvino CL, McNeil KA, Ong SC, Delaine C, Booker GW, Wallace JC, Whittaker J, Forbes BE. Alvino CL, et al. Among authors: forbes be. J Biol Chem. 2009 Mar 20;284(12):7656-64. doi: 10.1074/jbc.M808061200. Epub 2009 Jan 12. J Biol Chem. 2009. PMID: 19139090 Free PMC article.

5

Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.

Alvino CL, Ong SC, McNeil KA, Delaine C, Booker GW, Wallace JC, Forbes BE. Alvino CL, et al. Among authors: forbes be. PLoS One. 2011;6(11):e27488. doi: 10.1371/journal.pone.0027488. Epub 2011 Nov 28. PLoS One. 2011. PMID: 22140443 Free PMC article.

6

Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer.

Soh CL, McNeil K, Owczarek CM, Hardy MP, Fabri LJ, Pearse M, Delaine CA, Forbes BE. Soh CL, et al. Among authors: forbes be. Br J Cancer. 2014 Jun 10;110(12):2855-64. doi: 10.1038/bjc.2014.232. Epub 2014 May 22. Br J Cancer. 2014. PMID: 24853186 Free PMC article.

7

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC. Menting JG, et al. Among authors: forbes be. Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12. Nat Struct Mol Biol. 2016. PMID: 27617429

8

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.

van Lierop B, Ong SC, Belgi A, Delaine C, Andrikopoulos S, Haworth NL, Menting JG, Lawrence MC, Robinson AJ, Forbes BE. van Lierop B, et al. Among authors: forbes be. Sci Rep. 2017 Dec 8;7(1):17239. doi: 10.1038/s41598-017-16876-3. Sci Rep. 2017. PMID: 29222417 Free PMC article.

9

How ligand binds to the type 1 insulin-like growth factor receptor.

Xu Y, Kong GK, Menting JG, Margetts MB, Delaine CA, Jenkin LM, Kiselyov VV, De Meyts P, Forbes BE, Lawrence MC. Xu Y, et al. Among authors: forbes be. Nat Commun. 2018 Feb 26;9(1):821. doi: 10.1038/s41467-018-03219-7. Nat Commun. 2018. PMID: 29483580 Free PMC article.

10

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond.

Ong SC, Belgi A, van Lierop B, Delaine C, Andrikopoulos S, MacRaild CA, Norton RS, Haworth NL, Robinson AJ, Forbes BE. Ong SC, et al. Among authors: forbes be. J Biol Chem. 2018 Jul 27;293(30):11928-11943. doi: 10.1074/jbc.RA118.002486. Epub 2018 Jun 13. J Biol Chem. 2018. PMID: 29899115 Free PMC article.

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