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Page 1
TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.
MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. MacDonald BT, et al. Among authors: elowe nh. Mol Cell Proteomics. 2022 Apr;21(4):100223. doi: 10.1016/j.mcpro.2022.100223. Epub 2022 Mar 11. Mol Cell Proteomics. 2022. PMID: 35283288 Free PMC article.
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.
Wang M, Lee-Kim VS, Atri DS, Elowe NH, Yu J, Garvie CW, Won HH, Hadaya JE, MacDonald BT, Trindade K, Melander O, Rader DJ, Natarajan P, Kathiresan S, Kaushik VK, Khera AV, Gupta RM. Wang M, et al. Among authors: elowe nh. Circ Genom Precis Med. 2021 Oct;14(5):e003399. doi: 10.1161/CIRCGEN.121.003399. Epub 2021 Oct 1. Circ Genom Precis Med. 2021. PMID: 34592835 Free PMC article. Clinical Trial.
Development of a novel, sensitive cell-based corin assay.
Lambertz P, Theisen L, Längst N, Garvie CW, MacDonald BT, Yu J, Elowe NH, Zubov D, Kaushik VK, Wunder F. Lambertz P, et al. Among authors: elowe nh. Biochem Pharmacol. 2019 Feb;160:62-70. doi: 10.1016/j.bcp.2018.12.009. Epub 2018 Dec 13. Biochem Pharmacol. 2019. PMID: 30553787
Biochemical characterization of cholesteryl ester transfer protein inhibitors.
Ranalletta M, Bierilo KK, Chen Y, Milot D, Chen Q, Tung E, Houde C, Elowe NH, Garcia-Calvo M, Porter G, Eveland S, Frantz-Wattley B, Kavana M, Addona G, Sinclair P, Sparrow C, O'Neill EA, Koblan KS, Sitlani A, Hubbard B, Fisher TS. Ranalletta M, et al. Among authors: elowe nh. J Lipid Res. 2010 Sep;51(9):2739-52. doi: 10.1194/jlr.M007468. Epub 2010 May 10. J Lipid Res. 2010. PMID: 20458119 Free PMC article.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Xu J, Lin S, Myers RW, Addona G, Berger JP, Campbell B, Chen HS, Chen Z, Eiermann GJ, Elowe NH, Farrer BT, Feng W, Fu Q, Kats-Kagan R, Kavana M, Malkani S, McMasters DR, Mitra K, Pachanski MJ, Tong X, Trujillo ME, Xu L, Zhang B, Zhang F, Zhang R, Parmee ER. Xu J, et al. Among authors: elowe nh. Bioorg Med Chem Lett. 2017 May 1;27(9):2069-2073. doi: 10.1016/j.bmcl.2016.10.085. Epub 2016 Oct 31. Bioorg Med Chem Lett. 2017. PMID: 28284804
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Xu J, Lin S, Myers RW, Trujillo ME, Pachanski MJ, Malkani S, Chen HS, Chen Z, Campbell B, Eiermann GJ, Elowe N, Farrer BT, Feng W, Fu Q, Kats-Kagan R, Kavana M, McMasters DR, Mitra K, Tong X, Xu L, Zhang F, Zhang R, Addona GH, Berger JP, Zhang B, Parmee ER. Xu J, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2063-2068. doi: 10.1016/j.bmcl.2016.10.088. Epub 2016 Oct 31. Bioorg Med Chem Lett. 2017. PMID: 28284809
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
Isakovic L, Saavedra OM, Llewellyn DB, Claridge S, Zhan L, Bernstein N, Vaisburg A, Elowe N, Petschner AJ, Rahil J, Beaulieu N, Gauthier F, MacLeod AR, Delorme D, Besterman JM, Wahhab A. Isakovic L, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. doi: 10.1016/j.bmcl.2009.03.132. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19364644
20 results