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Priming of microglia in a DNA-repair deficient model of accelerated aging.
Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW. Raj DD, et al. Neurobiol Aging. 2014 Sep;35(9):2147-60. doi: 10.1016/j.neurobiolaging.2014.03.025. Epub 2014 Mar 28. Neurobiol Aging. 2014. PMID: 24799273 Free article.
Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing.
Schaafsma W, Zhang X, van Zomeren KC, Jacobs S, Georgieva PB, Wolf SA, Kettenmann H, Janova H, Saiepour N, Hanisch UK, Meerlo P, van den Elsen PJ, Brouwer N, Boddeke HW, Eggen BJ. Schaafsma W, et al. Brain Behav Immun. 2015 Aug;48:205-21. doi: 10.1016/j.bbi.2015.03.013. Epub 2015 Apr 2. Brain Behav Immun. 2015. PMID: 25843371
Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.
Raj DD, Moser J, van der Pol SM, van Os RP, Holtman IR, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW. Raj DD, et al. Aging Cell. 2015 Dec;14(6):1003-13. doi: 10.1111/acel.12370. Epub 2015 Aug 3. Aging Cell. 2015. PMID: 26238505 Free PMC article.
138 results