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Physiologically based kinetic (PBK) modeling as a new approach methodology (NAM) for predicting systemic levels of gut microbial metabolites.
Toxicol Lett. 2024 May 15;396:94-102. doi: 10.1016/j.toxlet.2024.04.013. Epub 2024 Apr 27.
Toxicol Lett. 2024.
PMID: 38685289
Free article.
Review.
Physiologically-Based Pharmacokinetic Modeling of the Postbiotic Supplement Urolithin A Predicts its Bioavailability Is Orders of Magnitude Lower than Concentrations that Induce Toxicity, but also Neuroprotective Effects.
Aichinger G, Stevanoska M, Beekmann K, Sturla SJ.
Aichinger G, et al. Among authors: stevanoska m.
Mol Nutr Food Res. 2023 Aug;67(15):e2300009. doi: 10.1002/mnfr.202300009. Epub 2023 Jun 13.
Mol Nutr Food Res. 2023.
PMID: 37195009
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Breaking through the barrier: Modelling and exploiting the physical microenvironment to enhance drug transport and efficacy.
Gładysz MZ, Stevanoska M, Włodarczyk-Biegun MK, Nagelkerke A.
Gładysz MZ, et al. Among authors: stevanoska m.
Adv Drug Deliv Rev. 2022 May;184:114183. doi: 10.1016/j.addr.2022.114183. Epub 2022 Mar 9.
Adv Drug Deliv Rev. 2022.
PMID: 35278523
Free article.
Review.
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