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Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.
Fata F, Gencheva R, Cheng Q, Lullo R, Ardini M, Silvestri I, Gabriele F, Ippoliti R, Bulman CA, Sakanari JA, Williams DL, Arnér ESJ, Angelucci F. Fata F, et al. Among authors: silvestri i. Redox Biol. 2022 May;51:102278. doi: 10.1016/j.redox.2022.102278. Epub 2022 Mar 4. Redox Biol. 2022. PMID: 35276442 Free PMC article.
Ectopic suicide inhibition of thioredoxin glutathione reductase.
Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Silvestri I, et al. Free Radic Biol Med. 2020 Feb 1;147:200-211. doi: 10.1016/j.freeradbiomed.2019.12.019. Epub 2019 Dec 20. Free Radic Biol Med. 2020. PMID: 31870799 Free PMC article.
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.
Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arnér ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Silvestri I, et al. ACS Chem Biol. 2018 Aug 17;13(8):2190-2202. doi: 10.1021/acschembio.8b00349. Epub 2018 Jun 11. ACS Chem Biol. 2018. PMID: 29800515 Free PMC article.
Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.
Fata F, Silvestri I, Ardini M, Ippoliti R, Di Leandro L, Demitri N, Polentarutti M, Di Matteo A, Lyu H, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Fata F, et al. Among authors: silvestri i. ACS Infect Dis. 2021 Jul 9;7(7):1932-1944. doi: 10.1021/acsinfecdis.0c00909. Epub 2021 May 5. ACS Infect Dis. 2021. PMID: 33950676 Free PMC article.
The folding and aggregation properties of a single KH-domain protein: Ribosome binding factor A (RbfA) from Pseudomonas aeruginosa.
Santorelli D, Rocchio S, Fata F, Silvestri I, Angelucci F, Imperi F, Marasco D, Diaferia C, Gigli L, Demitri N, Federici L, Di Matteo A, Travaglini-Allocatelli C. Santorelli D, et al. Among authors: silvestri i. Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129780. doi: 10.1016/j.bbagen.2020.129780. Epub 2020 Nov 4. Biochim Biophys Acta Gen Subj. 2021. PMID: 33157160
Protection of cells against oxidative stress by nanomolar levels of hydroxyflavones indicates a new type of intracellular antioxidant mechanism.
Lombardo E, Sabellico C, Hájek J, Staňková V, Filipský T, Balducci V, De Vito P, Leone S, Bavavea EI, Silvestri IP, Righi G, Luly P, Saso L, Bovicelli P, Pedersen JZ, Incerpi S. Lombardo E, et al. Among authors: silvestri ip. PLoS One. 2013 Apr 18;8(4):e60796. doi: 10.1371/journal.pone.0060796. Print 2013. PLoS One. 2013. PMID: 23637768 Free PMC article.
Efficient synthesis of scutellarein.
Righi G, Silvestri IP, Barontini M, Crisante F, Di Manno A, Pelagalli R, Bovicelli P. Righi G, et al. Nat Prod Res. 2012;26(14):1278-84. doi: 10.1080/14786419.2011.566224. Epub 2011 Oct 19. Nat Prod Res. 2012. PMID: 22007873
In vitro analysis of iron chelating activity of flavonoids.
Mladěnka P, Macáková K, Filipský T, Zatloukalová L, Jahodář L, Bovicelli P, Silvestri IP, Hrdina R, Saso L. Mladěnka P, et al. J Inorg Biochem. 2011 May;105(5):693-701. doi: 10.1016/j.jinorgbio.2011.02.003. Epub 2011 Feb 16. J Inorg Biochem. 2011. PMID: 21450273
87 results