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Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo.
Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, Nakamura K, Chen W, Chen Y, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Kershaw KM, Celeridad M, Pan S, Limpert AS, Sheffler DJ, Cosford NDP, Shiao SL, Tius MA, Lopez-Tapia F, Turkson J. Yue P, et al. Among authors: zhu y. Cancer Lett. 2022 May 28;534:215613. doi: 10.1016/j.canlet.2022.215613. Epub 2022 Mar 9. Cancer Lett. 2022. PMID: 35276290 Free PMC article.
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. Brotherton-Pleiss C, et al. Among authors: zhu y. J Med Chem. 2021 Jan 14;64(1):695-710. doi: 10.1021/acs.jmedchem.0c01705. Epub 2020 Dec 22. J Med Chem. 2021. PMID: 33352047 Free PMC article.
Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3.
Chen Y, Zhai N, Zhu Y, Yue P, Verma N, Brotherton-Pleiss C, Fu W, Nakamura K, Chen W, Kawakami J, Murali R, Tius MA, Lopez-Tapia F, Turkson J. Chen Y, et al. Among authors: zhu y. Bioorg Med Chem Lett. 2024 Jan 1;97:129565. doi: 10.1016/j.bmcl.2023.129565. Epub 2023 Nov 24. Bioorg Med Chem Lett. 2024. PMID: 38008341 Free article. No abstract available.
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