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Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo.
Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, Nakamura K, Chen W, Chen Y, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Kershaw KM, Celeridad M, Pan S, Limpert AS, Sheffler DJ, Cosford NDP, Shiao SL, Tius MA, Lopez-Tapia F, Turkson J. Yue P, et al. Among authors: chen j, chen w, chen y. Cancer Lett. 2022 May 28;534:215613. doi: 10.1016/j.canlet.2022.215613. Epub 2022 Mar 9. Cancer Lett. 2022. PMID: 35276290 Free PMC article.
Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. Brotherton-Pleiss C, et al. Among authors: chen j, chen w. J Med Chem. 2021 Jan 14;64(1):695-710. doi: 10.1021/acs.jmedchem.0c01705. Epub 2020 Dec 22. J Med Chem. 2021. PMID: 33352047 Free PMC article.
Consequences of PDGFRα+ fibroblast reduction in adult murine hearts.
Kuwabara JT, Hara A, Bhutada S, Gojanovich GS, Chen J, Hokutan K, Shettigar V, Lee AY, DeAngelo LP, Heckl JR, Jahansooz JR, Tacdol DK, Ziolo MT, Apte SS, Tallquist MD. Kuwabara JT, et al. Among authors: chen j. Elife. 2022 Sep 23;11:e69854. doi: 10.7554/eLife.69854. Elife. 2022. PMID: 36149056 Free PMC article.
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer.
Sun X, Verma SP, Jia G, Wang X, Ping J, Guo X, Shu XO, Chen J, Derkach A, Cai Q, Liang X, Long J, Offit K, Oh JH, Reiner AS, Watt GP, Woods M, Yang Y, Ambrosone CB, Ambs S, Chen Y, Concannon P, Garcia-Closas M, Gu J, Haiman CA, Hu JJ, Huo D, John EM, Knight JA, Li CI, Lynch CF, Mellemkjaer L, Nathanson KL, Nemesure B, Olopade OI, Olshan AF, Pal T, Palmer JR, Press MF, Sanderson M, Sandler DP, Troester MA, Zheng W, Bernstein JL, Buas MF, Shu X. Sun X, et al. Among authors: chen j. Cancer Res. 2024 Jun 4. doi: 10.1158/0008-5472.CAN-23-3854. Online ahead of print. Cancer Res. 2024. PMID: 38832928
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