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Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues.
Nelson CE, Namasivayam S, Foreman TW, Kauffman KD, Sakai S, Dorosky DE, Lora NE; NIAID/DIR Tuberculosis Imaging Program; Brooks K, Potter EL, Garza NL, Lafont BAP, Johnson RF, Roederer M, Sher A, Weiskopf D, Sette A, de Wit E, Hickman HD, Brenchley JM, Via LE, Barber DL. Nelson CE, et al. Among authors: lafont bap. Sci Immunol. 2022 Mar 10:eabo0535. doi: 10.1126/sciimmunol.abo0535. Online ahead of print. Sci Immunol. 2022. PMID: 35271298 Free PMC article.
Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells but fails to prevent disease.
Kubo M, Nishimura Y, Shingai M, Lee W, Brenchley J, Lafont B, Buckler-White A, Igarashi T, Martin MA. Kubo M, et al. J Virol. 2009 Jul;83(14):7099-108. doi: 10.1128/JVI.02522-08. Epub 2009 May 6. J Virol. 2009. PMID: 19420078 Free PMC article.
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.
Klatt NR, Harris LD, Vinton CL, Sung H, Briant JA, Tabb B, Morcock D, McGinty JW, Lifson JD, Lafont BA, Martin MA, Levine AD, Estes JD, Brenchley JM. Klatt NR, et al. Mucosal Immunol. 2010 Jul;3(4):387-98. doi: 10.1038/mi.2010.14. Epub 2010 Mar 31. Mucosal Immunol. 2010. PMID: 20357762 Free PMC article.
Simian Immunodeficiency Virus-Infected Memory CD4+ T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS.
Lee CA, Beasley E, Sundar K, Smelkinson M, Vinton C, Deleage C, Matsuda K, Wu F, Estes JD, Lafont BAP, Brenchley JM, Hirsch VM. Lee CA, et al. Among authors: lafont bap. mBio. 2020 Apr 21;11(2):e00602-20. doi: 10.1128/mBio.00602-20. mBio. 2020. PMID: 32317323 Free PMC article.
A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters.
Liu X, Luongo C, Matsuoka Y, Park HS, Santos C, Yang L, Moore IN, Afroz S, Johnson RF, Lafont BAP, Martens C, Best SM, Munster VJ, Hollý J, Yewdell JW, Le Nouën C, Munir S, Buchholz UJ. Liu X, et al. Among authors: lafont bap. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109744118. doi: 10.1073/pnas.2109744118. Proc Natl Acad Sci U S A. 2021. PMID: 34876520 Free PMC article.
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge.
Hilligan KL, Namasivayam S, Clancy CS, O'Mard D, Oland SD, Robertson SJ, Baker PJ, Castro E, Garza NL, Lafont BAP, Johnson R, Ronchese F, Mayer-Barber KD, Best SM, Sher A. Hilligan KL, et al. Among authors: lafont bap. J Exp Med. 2022 Feb 7;219(2):e20211862. doi: 10.1084/jem.20211862. Epub 2021 Dec 10. J Exp Med. 2022. PMID: 34889942 Free PMC article.
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