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Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation.
Eijgenraam TR, Stege NM, Oliveira Nunes Teixeira V, de Brouwer R, Schouten EM, Grote Beverborg N, Sun L, Später D, Knöll R, Hansson KM, Amilon C, Janzén D, Yeh ST, Mullick AE, van der Meer P, de Boer RA, Silljé HHW. Eijgenraam TR, et al. Among authors: knoll r. Int J Mol Sci. 2022 Feb 22;23(5):2427. doi: 10.3390/ijms23052427. Int J Mol Sci. 2022. PMID: 35269571 Free PMC article.
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, Boogerd CJ, Frisk M, van Rooij E, Damle S, Louch WE, Wang QD, Fritsche-Danielson R, Chien KR, Hansson KM, Mullick AE, de Boer RA, van der Meer P. Grote Beverborg N, et al. Among authors: knoll r. Nat Commun. 2021 Aug 30;12(1):5180. doi: 10.1038/s41467-021-25439-0. Nat Commun. 2021. PMID: 34462437 Free PMC article.
Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC).
de Boer RA, Heymans S, Backs J, Carrier L, Coats AJS, Dimmeler S, Eschenhagen T, Filippatos G, Gepstein L, Hulot JS, Knöll R, Kupatt C, Linke WA, Seidman CE, Tocchetti CG, van der Velden J, Walsh R, Seferovic PM, Thum T. de Boer RA, et al. Among authors: knoll r. Eur J Heart Fail. 2022 Mar;24(3):406-420. doi: 10.1002/ejhf.2414. Epub 2022 Jan 14. Eur J Heart Fail. 2022. PMID: 34969177 Free PMC article.
Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis.
Braumann S, Schumacher W, Im NG, Nettersheim FS, Mehrkens D, Bokredenghel S, Hof A, Nies RJ, Adler C, Winkels H, Knöll R, Freeman BA, Rudolph V, Klinke A, Adam M, Baldus S, Mollenhauer M, Geißen S. Braumann S, et al. Among authors: knoll r. Int J Mol Sci. 2021 Aug 22;22(16):9052. doi: 10.3390/ijms22169052. Int J Mol Sci. 2021. PMID: 34445757 Free PMC article.
Epigenetics and Heart Failure.
Ameer SS, Hossain MB, Knöll R. Ameer SS, et al. Among authors: knoll r. Int J Mol Sci. 2020 Nov 27;21(23):9010. doi: 10.3390/ijms21239010. Int J Mol Sci. 2020. PMID: 33260869 Free PMC article. Review.
The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)-Molecular Signature Differ with the Extent of RR.
Rodrigues PG, Miranda-Silva D, Li X, Sousa-Mendes C, Martins-Ferreira R, Elbeck Z, Leite-Moreira AF, Knöll R, Falcão-Pires I. Rodrigues PG, et al. Among authors: knoll r. Int J Mol Sci. 2020 Dec 18;21(24):9687. doi: 10.3390/ijms21249687. Int J Mol Sci. 2020. PMID: 33353134 Free PMC article.
Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes.
Ramachandra CJA, Kp MMJ, Chua J, Hernandez-Resendiz S, Liehn EA, Knöll R, Gan LM, Michaëlsson E, Jonsson MKB, Ryden-Markinhuhta K, Bhat RV, Fritsche-Danielson R, Lin YH, Sadayappan S, Tang HC, Wong P, Shim W, Hausenloy DJ. Ramachandra CJA, et al. Among authors: knoll r. Cardiovasc Res. 2022 Jan 29;118(2):517-530. doi: 10.1093/cvr/cvab077. Cardiovasc Res. 2022. PMID: 33705529 Free PMC article.
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, Folsche L, Hobbach AJ, von Frieling-Salewsky M, Unger A, Hucke A, Koser F, Kassner A, Sielemann K, Streckfuß-Bömeke K, Hasenfuss G, Goedel A, Laugwitz KL, Moretti A, Gummert JF, Dos Remedios CG, Reinecke H, Knöll R, van Heesch S, Hubner N, Zimmermann WH, Milting H, Linke WA. Fomin A, et al. Among authors: knoll r. Sci Transl Med. 2021 Nov 3;13(618):eabd3079. doi: 10.1126/scitranslmed.abd3079. Epub 2021 Nov 3. Sci Transl Med. 2021. PMID: 34731013
187 results