Gestwicki JE - Search Results

1

The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.

Opoku-Nsiah KA, de la Pena AH, Williams SK, Chopra N, Sali A, Lander GC, Gestwicki JE. Opoku-Nsiah KA, et al. Among authors: gestwicki je. Nat Commun. 2022 Mar 9;13(1):1226. doi: 10.1038/s41467-022-28864-x. Nat Commun. 2022. PMID: 35264557 Free PMC article.

2

Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration.

Opoku-Nsiah KA, Gestwicki JE. Opoku-Nsiah KA, et al. Among authors: gestwicki je. Transl Res. 2018 Aug;198:48-57. doi: 10.1016/j.trsl.2018.05.002. Epub 2018 Jun 19. Transl Res. 2018. PMID: 30244692 Free PMC article. Review.

3

Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.

Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Ravalin M, et al. Among authors: gestwicki je. Nat Chem Biol. 2019 Aug;15(8):786-794. doi: 10.1038/s41589-019-0322-6. Epub 2019 Jul 18. Nat Chem Biol. 2019. PMID: 31320752 Free PMC article.

4

A Phosphoramidate Strategy Enables Membrane Permeability of a Non-nucleotide Inhibitor of the Prolyl Isomerase Pin1.

Schwarz DMC, Williams SK, Dillenburg M, Wagner CR, Gestwicki JE. Schwarz DMC, et al. Among authors: gestwicki je. ACS Med Chem Lett. 2020 Aug 10;11(9):1704-1710. doi: 10.1021/acsmedchemlett.0c00170. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32944137 Free PMC article.

5

Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.

Carrettiero DC, Almeida MC, Longhini AP, Rauch JN, Han D, Zhang X, Najafi S, Gestwicki JE, Kosik KS. Carrettiero DC, et al. Among authors: gestwicki je. Nat Commun. 2022 Jun 2;13(1):3074. doi: 10.1038/s41467-022-30751-4. Nat Commun. 2022. PMID: 35654899 Free PMC article.

6

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.

Yee SW, Ferrández-Peral L, Alentorn-Moron P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Wolfreys FD, Yang J, Gestwicki JE, Capra JA, Artursson P, Newman JW, Marquès-Bonet T, Giacomini KM. Yee SW, et al. Among authors: gestwicki je. Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7. Nat Commun. 2024. PMID: 38782905 Free PMC article.

7

From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.

Pricer R, Gestwicki JE, Mapp AK. Pricer R, et al. Among authors: gestwicki je. Acc Chem Res. 2017 Mar 21;50(3):584-589. doi: 10.1021/acs.accounts.6b00565. Acc Chem Res. 2017. PMID: 28945413 Free PMC article.

8

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. Mok SA, et al. Among authors: gestwicki je. Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30. Nat Struct Mol Biol. 2018. PMID: 29728653 Free PMC article.

9

HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.

Glazier AA, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii AI, Lee LM, Shao H, Tang V, Yob JM, Gestwicki JE, Helms AS, Day SM. Glazier AA, et al. Among authors: gestwicki je. JCI Insight. 2018 Jun 7;3(11):e99319. doi: 10.1172/jci.insight.99319. eCollection 2018 Jun 7. JCI Insight. 2018. PMID: 29875314 Free PMC article.

10

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Freilich R, et al. Among authors: gestwicki je. Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4. Nat Commun. 2018. PMID: 30385828 Free PMC article.

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