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An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Chan S, Belmar N, Ho S, Rogers B, Stickler M, Graham M, Lee E, Tran N, Zhang D, Gupta P, Sho M, MacDonough T, Woolley A, Kim H, Zhang H, Liu W, Zheng P, Dezso Z, Halliwill K, Ceccarelli M, Rhodes S, Thakur A, Forsyth CM, Xiong M, Tan SS, Iyer R, Lake M, Digiammarino E, Zhou L, Bigelow L, Longenecker K, Judge RA, Liu C, Trumble M, Remis JP, Fox M, Cairns B, Akamatsu Y, Hollenbaugh D, Harding F, Alvarez HM. Chan S, et al. Among authors: iyer r. Nat Cancer. 2022 Mar;3(3):337-354. doi: 10.1038/s43018-022-00334-9. Epub 2022 Mar 7. Nat Cancer. 2022. PMID: 35256819 Free PMC article.
Empowering therapeutic antibodies with IFN-α for cancer immunotherapy.
Guo J, Xiao Y, Iyer R, Lu X, Lake M, Ladror U, Harlan J, Samanta T, Tomlinson M, Bukofzer G, Donawho C, Shoemaker A, Huang TH. Guo J, et al. Among authors: iyer r. PLoS One. 2019 Aug 8;14(8):e0219829. doi: 10.1371/journal.pone.0219829. eCollection 2019. PLoS One. 2019. PMID: 31393905 Free PMC article.
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
Argiriadi MA, Benatuil L, Dubrovska I, Egan DA, Gao L, Greischar A, Hardman J, Harlan J, Iyer RB, Judge RA, Lake M, Perron DC, Sadhukhan R, Sielaff B, Sousa S, Wang R, McRae BL. Argiriadi MA, et al. Among authors: iyer rb. BMC Mol Cell Biol. 2019 Aug 5;20(1):29. doi: 10.1186/s12860-019-0213-4. BMC Mol Cell Biol. 2019. PMID: 31382872 Free PMC article.
Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration.
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris MC, Clabbers A, Dong F, Shen J, Hackett SF, Touw DS, Bixby J, Zhong S, Benatuil L, Bose S, Grinnell C, Preston GM, Iyer R, Sadhukhan R, Marchie S, Overmeyer G, Ghayur T, van Riet DA, Tang S, Campochario PA, Gu J. Ding K, et al. Among authors: iyer r. MAbs. 2017 Feb/Mar;9(2):269-284. doi: 10.1080/19420862.2016.1268305. MAbs. 2017. PMID: 27929753 Free PMC article.
Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
Liu X, Shi Y, Maag DX, Palma JP, Patterson MJ, Ellis PA, Surber BW, Ready DB, Soni NB, Ladror US, Xu AJ, Iyer R, Harlan JE, Solomon LR, Donawho CK, Penning TD, Johnson EF, Shoemaker AR. Liu X, et al. Among authors: iyer r. Clin Cancer Res. 2012 Jan 15;18(2):510-23. doi: 10.1158/1078-0432.CCR-11-1973. Epub 2011 Nov 29. Clin Cancer Res. 2012. PMID: 22128301
Models using comprehensive, lesion-level, longitudinal [68Ga]Ga-DOTA-TATE PET-derived features lead to superior outcome prediction in neuroendocrine tumor patients treated with [177Lu]Lu-DOTA-TATE.
Santoro-Fernandes V, Schott B, Deatsch A, Keigley Q, Francken T, Iyer R, Fountzilas C, Perlman S, Jeraj R. Santoro-Fernandes V, et al. Among authors: iyer r. Eur J Nucl Med Mol Imaging. 2024 May 25. doi: 10.1007/s00259-024-06767-x. Online ahead of print. Eur J Nucl Med Mol Imaging. 2024. PMID: 38795121
Reducing postoperative hypothermia in infants: Quality improvement in China.
Qiu Q, Yang Z, Zhang Y, Zeng W, Yang K, Liang C, Alifu A, Huang H, Chen J, Zhang M, Wu D, Guo X, Jin S, Lin Y, Chuo J, Zhang H, Song X, Iyer RS. Qiu Q, et al. Among authors: iyer rs. Paediatr Anaesth. 2024 May 22. doi: 10.1111/pan.14910. Online ahead of print. Paediatr Anaesth. 2024. PMID: 38775778
CD8+ T cell targeting of tumor antigens presented by HLA-E.
Iyer RF, Verweij MC, Nair SS, Morrow D, Mansouri M, Chakravarty D, Beechwood T, Meyer C, Uebelhoer L, Lauron EJ, Selseth A, John N, Thin TH, Dzedzik S, Havenar-Daughton C, Axthelm MK, Douglas J, Korman A, Bhardwaj N, Tewari AK, Hansen S, Malouli D, Picker LJ, Früh K. Iyer RF, et al. Sci Adv. 2024 May 10;10(19):eadm7515. doi: 10.1126/sciadv.adm7515. Epub 2024 May 10. Sci Adv. 2024. PMID: 38728394 Free PMC article.
1,549 results