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PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production.
Srinivas US, Tay NSC, Jaynes P, Anbuselvan A, Ramachandran GK, Wardyn JD, Hoppe MM, Hoang PM, Peng Y, Lim S, Lee MY, Peethala PC, An O, Shendre A, Tan BWQ, Jemimah S, Lakshmanan M, Hu L, Jakhar R, Sachaphibulkij K, Lim LHK, Pervaiz S, Crasta K, Yang H, Tan P, Liang C, Ho L, Khanchandani V, Kappei D, Yong WP, Tan DSP, Bordi M, Campello S, Tam WL, Frezza C, Jeyasekharan AD. Srinivas US, et al. Among authors: an o. Oncogene. 2022 Mar;41(13):1986-2002. doi: 10.1038/s41388-022-02219-8. Epub 2022 Mar 2. Oncogene. 2022. PMID: 35236967
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers.
Kumar R, Coronel L, Somalanka B, Raju A, Aning OA, An O, Ho YS, Chen S, Mak SY, Hor PY, Yang H, Lakshmanan M, Itoh H, Tan SY, Lim YK, Wong APC, Chew SH, Huynh TH, Goh BC, Lim CY, Tergaonkar V, Cheok CF. Kumar R, et al. Among authors: an o. Nat Commun. 2018 Sep 26;9(1):3931. doi: 10.1038/s41467-018-05805-1. Nat Commun. 2018. PMID: 30258081 Free PMC article.
"3G" Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy.
An O, Song Y, Ke X, So JB, Sundar R, Yang H, Rha SY, Lee MH, Tay ST, Ong X, Tan ALK, Ng MCH, Tantoso E, Chen L, Tan P, Yong WP; Singapore Gastric Cancer Consortium (SGCC). An O, et al. Cancer Res. 2021 May 15;81(10):2788-2798. doi: 10.1158/0008-5472.CAN-20-2872. Epub 2021 Feb 8. Cancer Res. 2021. PMID: 33558338
T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival.
de Mel S, Mustafa N, Selvarajan V, Azaman MI, Jaynes PW, Venguidessane S, Phuong HM, Alnaseri ZT, Phyu T, Girard LP, Chng WJ, Wardyn J, Li Y, An O, Yang H, Ng SB, Jeyasekharan AD. de Mel S, et al. Among authors: an o. PLoS One. 2022 Jan 25;17(1):e0261469. doi: 10.1371/journal.pone.0261469. eCollection 2022. PLoS One. 2022. PMID: 35077445 Free PMC article.
p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain).
Teoh PJ, An O, Chung TH, Vaiyapuri T, Raju A, Hoppe MM, Toh SHM, Wang W, Chan MC, Fullwood MJ, Jeyasekharan AD, Tergaonkar V, Chen L, Yang H, Chng WJ. Teoh PJ, et al. Among authors: an o. Oncogene. 2022 Apr;41(14):2106-2121. doi: 10.1038/s41388-022-02227-8. Epub 2022 Feb 21. Oncogene. 2022. PMID: 35190641
42 results