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Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.
Wang YH, Ho TLF, Hariharan A, Goh HC, Wong YL, Verkaik NS, Lee MY, Tam WL, van Gent DC, Venkitaraman AR, Sheetz MP, Lane DP. Wang YH, et al. Among authors: venkitaraman ar. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2113233119. doi: 10.1073/pnas.2113233119. Epub 2022 Mar 2. Proc Natl Acad Sci U S A. 2022. PMID: 35235448 Free PMC article.
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.
Kong LR, Ong RW, Tan TZ, Mohamed Salleh NAB, Thangavelu M, Chan JV, Koh LYJ, Periyasamy G, Lau JA, Le TBU, Wang L, Lee M, Kannan S, Verma CS, Lim CM, Chng WJ, Lane DP, Venkitaraman A, Hung HT, Cheok CF, Goh BC. Kong LR, et al. Nat Commun. 2020 Apr 29;11(1):2086. doi: 10.1038/s41467-020-15608-y. Nat Commun. 2020. PMID: 32350249 Free PMC article.
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.
Ho TLF, Lee MY, Goh HC, Ng GYN, Lee JJH, Kannan S, Lim YT, Zhao T, Lim EKH, Phua CZJ, Lee YF, Lim RYX, Ng PJH, Yuan J, Chan DKH, Lieske B, Chong CS, Lee KC, Lum J, Cheong WK, Yeoh KG, Tan KK, Sobota RM, Verma CS, Lane DP, Tam WL, Venkitaraman AR. Ho TLF, et al. Among authors: venkitaraman ar. Nat Commun. 2023 Mar 28;14(1):1726. doi: 10.1038/s41467-023-37223-3. Nat Commun. 2023. PMID: 36977662 Free PMC article.
Involvement of Brca2 in DNA repair.
Patel KJ, Yu VP, Lee H, Corcoran A, Thistlethwaite FC, Evans MJ, Colledge WH, Friedman LS, Ponder BA, Venkitaraman AR. Patel KJ, et al. Among authors: venkitaraman ar. Mol Cell. 1998 Feb;1(3):347-57. doi: 10.1016/s1097-2765(00)80035-0. Mol Cell. 1998. PMID: 9660919 Free article.
DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells.
Jeyasekharan AD, Ayoub N, Mahen R, Ries J, Esposito A, Rajendra E, Hattori H, Kulkarni RP, Venkitaraman AR. Jeyasekharan AD, et al. Among authors: venkitaraman ar. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21937-42. doi: 10.1073/pnas.1009577107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098284 Free PMC article.
181 results