El-Khamisy SF - Search Results

1

Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease.

Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El-Khamisy SF. Palminha NM, et al. Cell Mol Life Sci. 2022 Feb 28;79(3):160. doi: 10.1007/s00018-022-04204-6. Cell Mol Life Sci. 2022. PMID: 35224690 Free PMC article.

2

Topoisomerase-mediated chromosomal break repair: an emerging player in many games.

Ashour ME, Atteya R, El-Khamisy SF. Ashour ME, et al. Nat Rev Cancer. 2015 Mar;15(3):137-51. doi: 10.1038/nrc3892. Epub 2015 Feb 19. Nat Rev Cancer. 2015. PMID: 25693836 Review.

3

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.

Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Meisenberg C, et al. Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026. Nucleic Acids Res. 2017. PMID: 28180300 Free PMC article.

4

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, Myszczynska MA, Alam SM, Garneret P, Chandran JS, Karyka E, Stopford MJ, Smith EF, Kirby J, Meyer K, Kaspar BK, Isaacs AM, El-Khamisy SF, De Vos KJ, Ning K, Azzouz M, Whitworth AJ, Shaw PJ. Hautbergue GM, et al. Nat Commun. 2017 Jul 5;8:16063. doi: 10.1038/ncomms16063. Nat Commun. 2017. PMID: 28677678 Free PMC article.

5

C9orf72 expansion disrupts ATM-mediated chromosomal break repair.

Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, Lukashchuk V, Chiang SC, Ray S, Mulcahy PJ, Jurga M, Tsagakis I, Iannitti T, Chandran J, Coldicott I, De Vos KJ, Hassan MK, Higginbottom A, Shaw PJ, Hautbergue GM, Azzouz M, El-Khamisy SF. Walker C, et al. Nat Neurosci. 2017 Sep;20(9):1225-1235. doi: 10.1038/nn.4604. Epub 2017 Jul 17. Nat Neurosci. 2017. PMID: 28714954 Free PMC article.

6

Studying TDP1 Function in DNA Repair.

Chiang SC, Liversidge K, El-Khamisy SF. Chiang SC, et al. Methods Mol Biol. 2018;1703:173-181. doi: 10.1007/978-1-4939-7459-7_13. Methods Mol Biol. 2018. PMID: 29177742

7

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.

Liao C, Beveridge R, Hudson JJR, Parker JD, Chiang SC, Ray S, Ashour ME, Sudbery I, Dickman MJ, El-Khamisy SF. Liao C, et al. Cell Rep. 2018 Jun 12;23(11):3352-3365. doi: 10.1016/j.celrep.2018.05.033. Cell Rep. 2018. PMID: 29898404 Free PMC article.

8

DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms.

Abugable AA, Morris JLM, Palminha NM, Zaksauskaite R, Ray S, El-Khamisy SF. Abugable AA, et al. DNA Repair (Amst). 2019 Sep;81:102669. doi: 10.1016/j.dnarep.2019.102669. Epub 2019 Jul 8. DNA Repair (Amst). 2019. PMID: 31331820 Free article. Review.

9

Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development.

Zaksauskaite R, Thomas RC, van Eeden F, El-Khamisy SF. Zaksauskaite R, et al. Sci Adv. 2021 Jan 29;7(5):eabc4165. doi: 10.1126/sciadv.abc4165. Print 2021 Jan. Sci Adv. 2021. PMID: 33514542 Free PMC article.

10

Hypoxia-induced SETX links replication stress with the unfolded protein response.

Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang MS, Victori P, Cheng WC, Buffa FM, Leszczynska KB, El-Khamisy SF, Gromak N, Hammond EM. Ramachandran S, et al. Nat Commun. 2021 Jun 17;12(1):3686. doi: 10.1038/s41467-021-24066-z. Nat Commun. 2021. PMID: 34140498 Free PMC article.

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