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Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival.
Abdulrahman Z, Santegoets SJ, Sturm G, Charoentong P, Ijsselsteijn ME, Somarakis A, Höllt T, Finotello F, Trajanoski Z, van Egmond SL, Mustafa DAM, Welters MJP, de Miranda NFCC, van der Burg SH. Abdulrahman Z, et al. Among authors: hollt t. J Immunother Cancer. 2022 Feb;10(2):e004346. doi: 10.1136/jitc-2021-004346. J Immunother Cancer. 2022. PMID: 35217577 Free PMC article.
The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival.
Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, Duurland CL, van Unen V, Höllt T, van der Velden LA, van Egmond SL, Kortekaas KE, de Vos van Steenwijk PJ, van Poelgeest MIE, Welters MJP, van der Burg SH. Santegoets SJ, et al. Among authors: hollt t. Clin Cancer Res. 2019 Jan 1;25(1):240-252. doi: 10.1158/1078-0432.CCR-18-1749. Epub 2018 Sep 17. Clin Cancer Res. 2019. PMID: 30224343
Memory CD4+ T cells are generated in the human fetal intestine.
Li N, van Unen V, Abdelaal T, Guo N, Kasatskaya SA, Ladell K, McLaren JE, Egorov ES, Izraelson M, Chuva de Sousa Lopes SM, Höllt T, Britanova OV, Eggermont J, de Miranda NFCC, Chudakov DM, Price DA, Lelieveldt BPF, Koning F. Li N, et al. Among authors: hollt t. Nat Immunol. 2019 Mar;20(3):301-312. doi: 10.1038/s41590-018-0294-9. Epub 2019 Jan 21. Nat Immunol. 2019. PMID: 30664737 Free PMC article.
Visual cohort comparison for spatial single-cell omics-data.
Somarakis A, Ijsselsteijn ME, Luk SJ, Kenkhuis B, de Miranda NFCC, Lelieveldt BPF, Hollt T. Somarakis A, et al. Among authors: hollt t. IEEE Trans Vis Comput Graph. 2021 Feb;27(2):733-743. doi: 10.1109/TVCG.2020.3030336. Epub 2021 Jan 28. IEEE Trans Vis Comput Graph. 2021. PMID: 33112747
Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients.
Kenkhuis B, Somarakis A, de Haan L, Dzyubachyk O, IJsselsteijn ME, de Miranda NFCC, Lelieveldt BPF, Dijkstra J, van Roon-Mom WMC, Höllt T, van der Weerd L. Kenkhuis B, et al. Among authors: hollt t. Acta Neuropathol Commun. 2021 Feb 17;9(1):27. doi: 10.1186/s40478-021-01126-5. Acta Neuropathol Commun. 2021. PMID: 33597025 Free PMC article.
40 results