LeGay R - Search Results

1

Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds.

Jose A, Guest D, LeGay R, Tizzard GJ, Coles SJ, Derveni M, Wright E, Marrison L, Lee AA, Morris A, Robinson M, von Delft F, Fearon D, Koekemoer L, Matviuk T, Aimon A, Schofield CJ, Malla TR, London N, Greenland BW, Bagley MC, Spencer J, The Covid Moonshot Consortium. Jose A, et al. Among authors: legay r. ChemMedChem. 2022 Apr 5;17(7):e202100641. doi: 10.1002/cmdc.202100641. Epub 2022 Feb 22. ChemMedChem. 2022. PMID: 35191598 Free PMC article.

2

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment.

Jourdan JP, Since M, El Kihel L, Lecoutey C, Corvaisier S, Legay R, Sopková-de Oliveira Santos J, Cresteil T, Malzert-Fréon A, Rochais C, Dallemagne P. Jourdan JP, et al. Among authors: legay r. ChemMedChem. 2017 Jun 21;12(12):913-916. doi: 10.1002/cmdc.201700102. Epub 2017 Apr 12. ChemMedChem. 2017. PMID: 28342294

3

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.

Jourdan JP, Since M, El Kihel L, Lecoutey C, Corvaisier S, Legay R, Sopkova-de Oliveira Santos J, Cresteil T, Malzert-Fréon A, Rochais C, Dallemagne P. Jourdan JP, et al. Among authors: legay r. Eur J Med Chem. 2016 May 23;114:365-79. doi: 10.1016/j.ejmech.2016.03.023. Epub 2016 Mar 12. Eur J Med Chem. 2016. PMID: 27046230

4

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.

Chosson E, Santoro F, Rochais C, Santos JS, Legay R, Thoret S, Cresteil T, Sinicropi MS, Besson T, Dallemagne P. Chosson E, et al. Among authors: legay r. Bioorg Med Chem. 2012 Apr 15;20(8):2614-23. doi: 10.1016/j.bmc.2012.02.043. Epub 2012 Mar 3. Bioorg Med Chem. 2012. PMID: 22429510

5

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P. Rochais C, et al. Among authors: legay r. J Med Chem. 2015 Apr 9;58(7):3172-87. doi: 10.1021/acs.jmedchem.5b00115. Epub 2015 Mar 31. J Med Chem. 2015. PMID: 25793650 Free article.

6

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT₄ receptors activities for the treatment of Alzheimer's disease.

Lalut J, Payan H, Davis A, Lecoutey C, Legay R, Sopkova-de Oliveira Santos J, Claeysen S, Dallemagne P, Rochais C. Lalut J, et al. Among authors: legay r. Sci Rep. 2020 Feb 20;10(1):3014. doi: 10.1038/s41598-020-59805-7. Sci Rep. 2020. PMID: 32080261 Free PMC article.

7

First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease.

Guieu B, Lecoutey C, Legay R, Davis A, Sopkova de Oliveira Santos J, Altomare CD, Catto M, Rochais C, Dallemagne P. Guieu B, et al. Among authors: legay r. Molecules. 2020 Dec 27;26(1):80. doi: 10.3390/molecules26010080. Molecules. 2020. PMID: 33375412 Free PMC article.

8

Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy.

Lecoutey C, Legay R, Davis A, Sopková-de Oliveira Santos J, Dallemagne P, Rochais C. Lecoutey C, et al. Among authors: legay r. Molecules. 2021 Apr 26;26(9):2536. doi: 10.3390/molecules26092536. Molecules. 2021. PMID: 33926141 Free PMC article.

9

Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.

Perri V, Rochais C, Sopkova-de Oliveira Santos J, Legay R, Cresteil T, Dallemagne P, Rault S. Perri V, et al. Among authors: legay r. Eur J Med Chem. 2010 Mar;45(3):1146-50. doi: 10.1016/j.ejmech.2009.12.021. Epub 2009 Dec 21. Eur J Med Chem. 2010. PMID: 20053482

10

N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.

Brossard D, Zhang Y, Haider SM, Sgobba M, Khalid M, Legay R, Duterque-Coquillaud M, Galera P, Rault S, Dallemagne P, Moslemi S, El Kihel L. Brossard D, et al. Among authors: legay r. Chem Biol Drug Des. 2013 Nov;82(5):620-9. doi: 10.1111/cbdd.12195. Chem Biol Drug Des. 2013. PMID: 23906044

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