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The S-layer homology domains of Paenibacillus alvei surface protein SpaA bind to cell wall polysaccharide through the terminal monosaccharide residue.
J Biol Chem. 2022 Apr;298(4):101745. doi: 10.1016/j.jbc.2022.101745. Epub 2022 Feb 18.
J Biol Chem. 2022.
PMID: 35189140
Free PMC article.
Antigen binding by conformational selection in near-germline antibodies.
Blackler RJ, Müller-Loennies S, Pokorny-Lehrer B, Legg MSG, Brade L, Brade H, Kosma P, Evans SV.
Blackler RJ, et al. Among authors: legg msg.
J Biol Chem. 2022 May;298(5):101901. doi: 10.1016/j.jbc.2022.101901. Epub 2022 Apr 6.
J Biol Chem. 2022.
PMID: 35395245
Free PMC article.
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Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Gagnon SML, Legg MSG, Polakowski R, Letts JA, Persson M, Lin S, Zheng RB, Rempel B, Schuman B, Haji-Ghassemi O, Borisova SN, Palcic MM, Evans SV.
Gagnon SML, et al. Among authors: legg msg.
Glycobiology. 2018 Aug 1;28(8):624-636. doi: 10.1093/glycob/cwy051.
Glycobiology. 2018.
PMID: 29873711
Free PMC article.
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Monoclonal antibody 7H2.2 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered.
Legg MSG, Gagnon SML, Powell CJ, Boulanger MJ, Li AJJ, Evans SV.
Legg MSG, et al.
Acta Crystallogr D Struct Biol. 2022 May 1;78(Pt 5):623-632. doi: 10.1107/S2059798322003011. Epub 2022 Apr 20.
Acta Crystallogr D Struct Biol. 2022.
PMID: 35503210
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High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Gagnon SML, Legg MSG, Sindhuwinata N, Letts JA, Johal AR, Schuman B, Borisova SN, Palcic MM, Peters T, Evans SV.
Gagnon SML, et al. Among authors: legg msg.
Glycobiology. 2017 Oct 1;27(10):966-977. doi: 10.1093/glycob/cwx053.
Glycobiology. 2017.
PMID: 28575295
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Temperature-sensitive recombinant subtilisin protease variants that efficiently degrade molecular biology enzymes.
Thompson VC, McGuire BE, Frier MS, Legg MSG, Dyer TW, Gudavicius G, Potter S, Nano FE.
Thompson VC, et al. Among authors: legg msg.
FEMS Microbiol Lett. 2020 Oct 16;367(19):fnaa162. doi: 10.1093/femsle/fnaa162.
FEMS Microbiol Lett. 2020.
PMID: 33016320
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