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Antigen binding by conformational selection in near-germline antibodies.
Blackler RJ, Müller-Loennies S, Pokorny-Lehrer B, Legg MSG, Brade L, Brade H, Kosma P, Evans SV. Blackler RJ, et al. Among authors: legg msg. J Biol Chem. 2022 May;298(5):101901. doi: 10.1016/j.jbc.2022.101901. Epub 2022 Apr 6. J Biol Chem. 2022. PMID: 35395245 Free PMC article.
Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.
Gagnon SML, Legg MSG, Polakowski R, Letts JA, Persson M, Lin S, Zheng RB, Rempel B, Schuman B, Haji-Ghassemi O, Borisova SN, Palcic MM, Evans SV. Gagnon SML, et al. Among authors: legg msg. Glycobiology. 2018 Aug 1;28(8):624-636. doi: 10.1093/glycob/cwy051. Glycobiology. 2018. PMID: 29873711 Free PMC article.
High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Gagnon SML, Legg MSG, Sindhuwinata N, Letts JA, Johal AR, Schuman B, Borisova SN, Palcic MM, Peters T, Evans SV. Gagnon SML, et al. Among authors: legg msg. Glycobiology. 2017 Oct 1;27(10):966-977. doi: 10.1093/glycob/cwx053. Glycobiology. 2017. PMID: 28575295