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Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment.
Hirt CK, Booij TH, Grob L, Simmler P, Toussaint NC, Keller D, Taube D, Ludwig V, Goryachkin A, Pauli C, Lenggenhager D, Stekhoven DJ, Stirnimann CU, Endhardt K, Ringnalda F, Villiger L, Siebenhüner A, Karkampouna S, De Menna M, Beshay J, Klett H, Kruithof-de Julio M, Schüler J, Schwank G. Hirt CK, et al. Among authors: simmler p. Cell Genom. 2022 Feb;2(2):100095. doi: 10.1016/j.xgen.2022.100095. Cell Genom. 2022. PMID: 35187519 Free PMC article.
SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer.
Simmler P, Cortijo C, Koch LM, Galliker P, Angori S, Bolck HA, Mueller C, Vukolic A, Mirtschink P, Christinat Y, Davidson NR, Lehmann KV, Pellegrini G, Pauli C, Lenggenhager D, Guccini I, Ringel T, Hirt C, Marquart KF, Schaefer M, Rätsch G, Peter M, Moch H, Stoffel M, Schwank G. Simmler P, et al. Cell Rep. 2022 Aug 23;40(8):111266. doi: 10.1016/j.celrep.2022.111266. Cell Rep. 2022. PMID: 36001976 Free article.
Mutant SF3B1 promotes malignancy in PDAC.
Simmler P, Ioannidi EI, Mengis T, Marquart KF, Asawa S, Van-Lehmann K, Kahles A, Thomas T, Schwerdel C, Aceto N, Rätsch G, Stoffel M, Schwank G. Simmler P, et al. Elife. 2023 Oct 12;12:e80683. doi: 10.7554/eLife.80683. Elife. 2023. PMID: 37823551 Free PMC article.
Accuracy to 2nd International HIV-1 RNA WHO Standard: assessment of three generations of quantitative HIV-1 RNA nucleic acid amplification tests.
Glaubitz J, Sizmann D, Simon CO, Hoffmann KS, Drogan D, Hesse M, Lang G, Kroeh M, Simmler P, Dewald M, Haberhausen G, Lindauer A, Beyser K, Reber A, Baumeister A, Wolf E, Jaeger H, Babiel R. Glaubitz J, et al. Among authors: simmler p. J Clin Virol. 2011 Feb;50(2):119-24. doi: 10.1016/j.jcv.2010.10.017. Epub 2010 Nov 24. J Clin Virol. 2011. PMID: 21109484
Improved HIV-1 RNA quantitation by COBAS AmpliPrep/COBAS TaqMan HIV-1 Test, v2.0 using a novel dual-target approach.
Sizmann D, Glaubitz J, Simon CO, Goedel S, Buergisser P, Drogan D, Hesse M, Kröh M, Simmler P, Dewald M, Gilsdorf M, Fuerst M, Ineichen R, Kirn A, Pasche P, Wang Z, Weisshaar S, Young K, Haberhausen G, Babiel R. Sizmann D, et al. Among authors: simmler p. J Clin Virol. 2010 Sep;49(1):41-6. doi: 10.1016/j.jcv.2010.06.004. Epub 2010 Jul 15. J Clin Virol. 2010. PMID: 20637687