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High-Throughput Screen for Inhibitors of Klebsiella pneumoniae Virulence Using a Tetrahymena pyriformis Co-Culture Surrogate Host Model.
Woods AL, Parker D, Glick MM, Peng Y, Lenoir F, Mulligan E, Yu V, Piizzi G, Lister T, Lilly MD, Dzink-Fox J, Jansen JM, Ryder NS, Dean CR, Smith TM. Woods AL, et al. Among authors: ryder ns. ACS Omega. 2022 Feb 1;7(6):5401-5414. doi: 10.1021/acsomega.1c06633. eCollection 2022 Feb 15. ACS Omega. 2022. PMID: 35187355 Free PMC article.
Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.
Dean CR, Narayan S, Richards J, Daigle DM, Esterow S, Leeds JA, Kamp H, Puyang X, Wiedmann B, Mueller D, Voshol H, van Oostrum J, Wall D, Koehn J, Dzink-Fox J, Ryder NS. Dean CR, et al. Among authors: ryder ns. Antimicrob Agents Chemother. 2007 Mar;51(3):1004-10. doi: 10.1128/AAC.01103-06. Epub 2007 Jan 12. Antimicrob Agents Chemother. 2007. PMID: 17220413 Free PMC article.
A collaborative hit-to-lead investigation leveraging medicinal chemistry expertise with high throughput library design, synthesis and purification capabilities.
Yang X, Parker D, Whitehead L, Ryder NS, Weidmann B, Stabile-Harris M, Kizer D, McKinnon M, Smellie A, Powers D. Yang X, et al. Among authors: ryder ns. Comb Chem High Throughput Screen. 2006 Feb;9(2):123-30. doi: 10.2174/138620706775541891. Comb Chem High Throughput Screen. 2006. PMID: 16475970
Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.
Richie DL, Thompson KV, Studer C, Prindle VC, Aust T, Riedl R, Estoppey D, Tao J, Sexton JA, Zabawa T, Drumm J, Cotesta S, Eichenberger J, Schuierer S, Hartmann N, Movva NR, Tallarico JA, Ryder NS, Hoepfner D. Richie DL, et al. Among authors: ryder ns. Antimicrob Agents Chemother. 2013 May;57(5):2272-80. doi: 10.1128/AAC.01809-12. Epub 2013 Mar 11. Antimicrob Agents Chemother. 2013. PMID: 23478965 Free PMC article.
Peptide deformylase inhibitors as potent antimycobacterial agents.
Teo JW, Thayalan P, Beer D, Yap AS, Nanjundappa M, Ngew X, Duraiswamy J, Liung S, Dartois V, Schreiber M, Hasan S, Cynamon M, Ryder NS, Yang X, Weidmann B, Bracken K, Dick T, Mukherjee K. Teo JW, et al. Among authors: ryder ns. Antimicrob Agents Chemother. 2006 Nov;50(11):3665-73. doi: 10.1128/AAC.00555-06. Epub 2006 Sep 11. Antimicrob Agents Chemother. 2006. PMID: 16966397 Free PMC article.
74 results