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Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA. Chen Q, et al. Among authors: covelli dj. J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1. J Med Chem. 2023. PMID: 36724486 Free PMC article.
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
Rao SD, Chen Q, Wang Q, Orth-He EL, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Huang HC, Chui AJ, Covelli DJ, You S, Cross JR, Bachovchin DA. Rao SD, et al. Among authors: covelli dj. Nat Chem Biol. 2022 May;18(5):565-574. doi: 10.1038/s41589-021-00964-7. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165443 Free PMC article.