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The role of Drosophila Piezo in mechanical nociception.
Kim SE, Coste B, Chadha A, Cook B, Patapoutian A. Kim SE, et al. Among authors: patapoutian a. Nature. 2012 Feb 19;483(7388):209-12. doi: 10.1038/nature10801. Nature. 2012. PMID: 22343891 Free PMC article.
Piezo proteins are pore-forming subunits of mechanically activated channels.
Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A. Coste B, et al. Among authors: patapoutian a. Nature. 2012 Feb 19;483(7388):176-81. doi: 10.1038/nature10812. Nature. 2012. PMID: 22343900 Free PMC article.
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.
Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, Philippakis A, Hoischen A, Riemer G, Steen U, Steen VM, Mathur J, Cox J, Lebo M, Rehm H, Weiss ST, Wood JN, Maas RL, Sunyaev SR, Patapoutian A. Coste B, et al. Among authors: patapoutian a. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4667-72. doi: 10.1073/pnas.1221400110. Epub 2013 Mar 4. Proc Natl Acad Sci U S A. 2013. PMID: 23487782 Free PMC article.
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels.
Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, Fénéant-Thibault M, Tertian G, de Jaureguiberry JP, Syfuss PY, Cahalan S, Garçon L, Toutain F, Simon Rohrlich P, Delaunay J, Picard V, Jeunemaitre X, Patapoutian A. Albuisson J, et al. Among authors: patapoutian a. Nat Commun. 2013;4:1884. doi: 10.1038/ncomms2899. Nat Commun. 2013. PMID: 23695678 Free PMC article.
Piezo2 is required for Merkel-cell mechanotransduction.
Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A. Woo SH, et al. Among authors: patapoutian a. Nature. 2014 May 29;509(7502):622-6. doi: 10.1038/nature13251. Epub 2014 Apr 6. Nature. 2014. PMID: 24717433 Free PMC article.
121 results