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A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.
Bezerra Bellei JC, Glanzmann N, Carpinter BA, Renhe DC, Marques CB, Azevedo MR, Barreto LM, Rocha VN, Karine da Costa Nunes I, Gualberto Pereira HM, Coimbra ES, Ferraz Coelho EA, David da Silva A, de Pilla Varotti F, Gorza Scopel KK. Bezerra Bellei JC, et al. Among authors: gorza scopel kk. Chem Biol Interact. 2022 Mar 1;355:109848. doi: 10.1016/j.cbi.2022.109848. Epub 2022 Feb 9. Chem Biol Interact. 2022. PMID: 35149084
Novel organic salts based on quinoline derivatives: The in vitro activity trigger apoptosis inhibiting autophagy in Leishmania spp.
Calixto SL, Glanzmann N, Xavier Silveira MM, da Trindade Granato J, Gorza Scopel KK, Torres de Aguiar T, DaMatta RA, Macedo GC, da Silva AD, Coimbra ES. Calixto SL, et al. Among authors: gorza scopel kk. Chem Biol Interact. 2018 Sep 25;293:141-151. doi: 10.1016/j.cbi.2018.08.003. Epub 2018 Aug 9. Chem Biol Interact. 2018. PMID: 30098941
In Vitro and in Vivo Antimalarial Activity, Cytotoxicity and Phytochemical HRMS2 Profile of Plants from the Western Pará State, Brazilian Amazonia.
Viana Dos Santos MB, Costa Gontijo D, Alves do Nascimento MF, de Paula RC, Bezerra Bellei JC, Raimundo FO, Gorza Scopel KK, de Oliveira AB, Veras Mourão RH. Viana Dos Santos MB, et al. Among authors: gorza scopel kk. Chem Biodivers. 2024 Jan;21(1):e202301082. doi: 10.1002/cbdv.202301082. Epub 2023 Dec 5. Chem Biodivers. 2024. PMID: 38012088