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A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.
Bezerra Bellei JC, Glanzmann N, Carpinter BA, Renhe DC, Marques CB, Azevedo MR, Barreto LM, Rocha VN, Karine da Costa Nunes I, Gualberto Pereira HM, Coimbra ES, Ferraz Coelho EA, David da Silva A, de Pilla Varotti F, Gorza Scopel KK. Bezerra Bellei JC, et al. Among authors: david da silva a. Chem Biol Interact. 2022 Mar 1;355:109848. doi: 10.1016/j.cbi.2022.109848. Epub 2022 Feb 9. Chem Biol Interact. 2022. PMID: 35149084
In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization.
Marinho JA, Martins Guimarães DS, Glanzmann N, de Almeida Pimentel G, Karine da Costa Nunes I, Gualberto Pereira HM, Navarro M, de Pilla Varotti F, David da Silva A, Abramo C. Marinho JA, et al. Among authors: david da silva a. Eur J Med Chem. 2021 Apr 5;215:113271. doi: 10.1016/j.ejmech.2021.113271. Epub 2021 Feb 8. Eur J Med Chem. 2021. PMID: 33596489