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A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.
Bezerra Bellei JC, Glanzmann N, Carpinter BA, Renhe DC, Marques CB, Azevedo MR, Barreto LM, Rocha VN, Karine da Costa Nunes I, Gualberto Pereira HM, Coimbra ES, Ferraz Coelho EA, David da Silva A, de Pilla Varotti F, Gorza Scopel KK. Bezerra Bellei JC, et al. Among authors: coimbra es. Chem Biol Interact. 2022 Mar 1;355:109848. doi: 10.1016/j.cbi.2022.109848. Epub 2022 Feb 9. Chem Biol Interact. 2022. PMID: 35149084
Novel organic salts based on quinoline derivatives: The in vitro activity trigger apoptosis inhibiting autophagy in Leishmania spp.
Calixto SL, Glanzmann N, Xavier Silveira MM, da Trindade Granato J, Gorza Scopel KK, Torres de Aguiar T, DaMatta RA, Macedo GC, da Silva AD, Coimbra ES. Calixto SL, et al. Among authors: coimbra es. Chem Biol Interact. 2018 Sep 25;293:141-151. doi: 10.1016/j.cbi.2018.08.003. Epub 2018 Aug 9. Chem Biol Interact. 2018. PMID: 30098941
Novel functionalized 1,2,3-triazole derivatives exhibit antileishmanial activity, increase in total and mitochondrial-ROS and depolarization of mitochondrial membrane potential of Leishmania amazonensis.
Meinel RS, Almeida ADC, Stroppa PHF, Glanzmann N, Coimbra ES, da Silva AD. Meinel RS, et al. Among authors: coimbra es. Chem Biol Interact. 2020 Jan 5;315:108850. doi: 10.1016/j.cbi.2019.108850. Epub 2019 Oct 18. Chem Biol Interact. 2020. PMID: 31634447
Functionalized 1,2,3-triazolium salts as potential agents against visceral leishmaniasis.
das Chagas Almeida A, Meinel RS, Leal YL, Silva TP, Glanzmann N, Mendonça DVC, Perin L, Cunha-Júnior EF, Coelho EAF, Melo RCN, da Silva AD, Coimbra ES. das Chagas Almeida A, et al. Among authors: coimbra es. Parasitol Res. 2022 May;121(5):1389-1406. doi: 10.1007/s00436-022-07431-9. Epub 2022 Feb 16. Parasitol Res. 2022. PMID: 35169883
93 results