Gestwicki JE - Search Results

1

Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities.

Johnson OT, Nadel CM, Carroll EC, Arhar T, Gestwicki JE. Johnson OT, et al. Among authors: gestwicki je. J Biol Chem. 2022 Mar;298(3):101697. doi: 10.1016/j.jbc.2022.101697. Epub 2022 Feb 9. J Biol Chem. 2022. PMID: 35148989 Free PMC article.

2

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

Evans CG, Wisén S, Gestwicki JE. Evans CG, et al. Among authors: gestwicki je. J Biol Chem. 2006 Nov 3;281(44):33182-91. doi: 10.1074/jbc.M606192200. Epub 2006 Sep 14. J Biol Chem. 2006. PMID: 16973602 Free article.

3

Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.

Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Wang AM, et al. Among authors: gestwicki je. J Biol Chem. 2010 May 21;285(21):15714-23. doi: 10.1074/jbc.M109.098806. Epub 2010 Mar 26. J Biol Chem. 2010. PMID: 20348093 Free PMC article.

4

Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK).

Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Chang L, et al. Among authors: gestwicki je. J Biol Chem. 2010 Jul 9;285(28):21282-91. doi: 10.1074/jbc.M110.124149. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439464 Free PMC article.

5

Allostery in the Hsp70 chaperone proteins.

Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE, Ahmad A. Zuiderweg ER, et al. Among authors: gestwicki je. Top Curr Chem. 2013;328:99-153. doi: 10.1007/128_2012_323. Top Curr Chem. 2013. PMID: 22576356 Free PMC article. Review.

6

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

Rauch JN, Gestwicki JE. Rauch JN, et al. Among authors: gestwicki je. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 Dec 5. J Biol Chem. 2014. PMID: 24318877 Free PMC article.

7

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. Connarn JN, et al. Among authors: gestwicki je. J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. J Biol Chem. 2014. PMID: 24327656 Free PMC article.

8

Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.

Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Jaeger AM, et al. Among authors: gestwicki je. J Biol Chem. 2014 Oct 31;289(44):30459-30469. doi: 10.1074/jbc.M114.591578. Epub 2014 Sep 9. J Biol Chem. 2014. PMID: 25204655 Free PMC article.

9

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA. Fontaine SN, et al. Among authors: gestwicki je. J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11. J Biol Chem. 2015. PMID: 25864199 Free PMC article.

10

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE. Assimon VA, et al. Among authors: gestwicki je. Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25. Biochemistry. 2015. PMID: 26565746 Free PMC article.

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