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Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway.
J Exp Clin Cancer Res. 2022 Feb 11;41(1):60. doi: 10.1186/s13046-022-02271-y.
J Exp Clin Cancer Res. 2022.
PMID: 35148799
Free PMC article.
MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth.
Colladel R, Pellicani R, Andreuzzi E, Paulitti A, Tarticchio G, Todaro F, Colombatti A, Mongiat M.
Colladel R, et al. Among authors: tarticchio g.
Oncotarget. 2016 Jan 12;7(2):2022-37. doi: 10.18632/oncotarget.6515.
Oncotarget. 2016.
PMID: 26655500
Free PMC article.
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Extracellular Matrix, a Hard Player in Angiogenesis.
Mongiat M, Andreuzzi E, Tarticchio G, Paulitti A.
Mongiat M, et al. Among authors: tarticchio g.
Int J Mol Sci. 2016 Nov 1;17(11):1822. doi: 10.3390/ijms17111822.
Int J Mol Sci. 2016.
PMID: 27809279
Free PMC article.
Review.
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The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.
Andreuzzi E, Colladel R, Pellicani R, Tarticchio G, Cannizzaro R, Spessotto P, Bussolati B, Brossa A, De Paoli P, Canzonieri V, Iozzo RV, Colombatti A, Mongiat M.
Andreuzzi E, et al. Among authors: tarticchio g.
Matrix Biol. 2017 Dec;64:40-53. doi: 10.1016/j.matbio.2017.04.002. Epub 2017 Apr 21.
Matrix Biol. 2017.
PMID: 28435016
Free article.
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Multimerin-2 maintains vascular stability and permeability.
Pellicani R, Poletto E, Andreuzzi E, Paulitti A, Doliana R, Bizzotto D, Braghetta P, Colladel R, Tarticchio G, Sabatelli P, Bucciotti F, Bressan G, Iozzo RV, Colombatti A, Bonaldo P, Mongiat M.
Pellicani R, et al. Among authors: tarticchio g.
Matrix Biol. 2020 May;87:11-25. doi: 10.1016/j.matbio.2019.08.002. Epub 2019 Aug 15.
Matrix Biol. 2020.
PMID: 31422156
Free article.
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The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth.
Paulitti A, Andreuzzi E, Bizzotto D, Pellicani R, Tarticchio G, Marastoni S, Pastrello C, Jurisica I, Ligresti G, Bucciotti F, Doliana R, Colladel R, Braghetta P, Poletto E, Di Silvestre A, Bressan G, Colombatti A, Bonaldo P, Mongiat M.
Paulitti A, et al. Among authors: tarticchio g.
Oncogene. 2018 Jun;37(25):3399-3414. doi: 10.1038/s41388-017-0107-x. Epub 2018 Feb 27.
Oncogene. 2018.
PMID: 29483644
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Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium.
Galvagni F, Nardi F, Spiga O, Trezza A, Tarticchio G, Pellicani R, Andreuzzi E, Caldi E, Toti P, Tosi GM, Santucci A, Iozzo RV, Mongiat M, Orlandini M.
Galvagni F, et al. Among authors: tarticchio g.
Matrix Biol. 2017 Dec;64:112-127. doi: 10.1016/j.matbio.2017.08.003. Epub 2017 Sep 11.
Matrix Biol. 2017.
PMID: 28912033
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