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In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
Nat Commun. 2022 Feb 8;13(1):750. doi: 10.1038/s41467-022-28358-w.
Nat Commun. 2022.
PMID: 35136065
Free PMC article.
A homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly.
Di Nottia M, Marchese M, Verrigni D, Mutti CD, Torraco A, Oliva R, Fernandez-Vizarra E, Morani F, Trani G, Rizza T, Ghezzi D, Ardissone A, Nesti C, Vasco G, Zeviani M, Minczuk M, Bertini E, Santorelli FM, Carrozzo R.
Di Nottia M, et al. Among authors: mutti cd.
Neurobiol Dis. 2020 Jul;141:104880. doi: 10.1016/j.nbd.2020.104880. Epub 2020 Apr 25.
Neurobiol Dis. 2020.
PMID: 32344152
Free article.
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YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria.
D'Souza AR, Van Haute L, Powell CA, Mutti CD, Páleníková P, Rebelo-Guiomar P, Rorbach J, Minczuk M.
D'Souza AR, et al. Among authors: mutti cd.
Nucleic Acids Res. 2021 Jun 4;49(10):5798-5812. doi: 10.1093/nar/gkab404.
Nucleic Acids Res. 2021.
PMID: 34037799
Free PMC article.
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Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs.
Schöller E, Marks J, Marchand V, Bruckmann A, Powell CA, Reichold M, Mutti CD, Dettmer K, Feederle R, Hüttelmaier S, Helm M, Oefner P, Minczuk M, Motorin Y, Hafner M, Meister G.
Schöller E, et al. Among authors: mutti cd.
Mol Cell. 2021 Dec 2;81(23):4810-4825.e12. doi: 10.1016/j.molcel.2021.10.018. Epub 2021 Nov 12.
Mol Cell. 2021.
PMID: 34774131
Free article.
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The human mitochondrial genome contains a second light strand promoter.
Tan BG, Mutti CD, Shi Y, Xie X, Zhu X, Silva-Pinheiro P, Menger KE, Díaz-Maldonado H, Wei W, Nicholls TJ, Chinnery PF, Minczuk M, Falkenberg M, Gustafsson CM.
Tan BG, et al. Among authors: mutti cd.
Mol Cell. 2022 Oct 6;82(19):3646-3660.e9. doi: 10.1016/j.molcel.2022.08.011. Epub 2022 Aug 30.
Mol Cell. 2022.
PMID: 36044900
Free article.
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A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome.
Silva-Pinheiro P, Mutti CD, Van Haute L, Powell CA, Nash PA, Turner K, Minczuk M.
Silva-Pinheiro P, et al. Among authors: mutti cd.
Nat Biomed Eng. 2023 May;7(5):692-703. doi: 10.1038/s41551-022-00968-1. Epub 2022 Dec 5.
Nat Biomed Eng. 2023.
PMID: 36470976
Free PMC article.
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