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Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS.
Camperi J, Grunert I, Heinrich K, Winter M, Özipek S, Hoelterhoff S, Weindl T, Mayr K, Bulau P, Meier M, Mølhøj M, Leiss M, Guillarme D, Bathke A, Stella C. Camperi J, et al. Among authors: leiss m. Talanta. 2021 Nov 1;234:122628. doi: 10.1016/j.talanta.2021.122628. Epub 2021 Jun 18. Talanta. 2021. PMID: 34364437
From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies.
Goyon A, Dai L, Chen T, Wei B, Yang F, Andersen N, Kopf R, Leiss M, Mølhøj M, Guillarme D, Stella C. Goyon A, et al. Among authors: leiss m. J Chromatogr A. 2020 Mar 29;1615:460740. doi: 10.1016/j.chroma.2019.460740. Epub 2019 Nov 27. J Chromatogr A. 2020. PMID: 31796250
Expediting online liquid chromatography for real-time monitoring of product attributes to advance process analytical technology in downstream processing of biopharmaceuticals.
Graf T, Naumann L, Bonnington L, Heckel J, Spensberger B, Klein S, Brey C, Nachtigall R, Mroz M, Hogg TV, McHardy C, Martinez A, Braaz R, Leiss M. Graf T, et al. Among authors: leiss m. J Chromatogr A. 2024 May 21;1729:465013. doi: 10.1016/j.chroma.2024.465013. Online ahead of print. J Chromatogr A. 2024. PMID: 38824753 Free article.
19 results