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Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Gerndt S, et al. Among authors: yuan y. Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712. Elife. 2020. PMID: 32167471 Free PMC article.
The lysosomotrope GPN mobilises Ca2+ from acidic organelles.
Yuan Y, Kilpatrick BS, Gerndt S, Bracher F, Grimm C, Schapira AH, Patel S. Yuan Y, et al. J Cell Sci. 2021 Mar 11;134(6):jcs256578. doi: 10.1242/jcs.256578. J Cell Sci. 2021. PMID: 33602742 Free PMC article.
Teaming with NAADP.
Patel S, Gregori M, Yuan Y. Patel S, et al. Among authors: yuan y. Sci Signal. 2021 Mar 23;14(675):eabh2798. doi: 10.1126/scisignal.abh2798. Sci Signal. 2021. PMID: 33758059 Review.
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.
Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S. Yuan Y, et al. Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0. Nat Commun. 2022. PMID: 35918320 Free PMC article.
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