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Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
Latorre R, Hegron A, Peach CJ, Teng S, Tonello R, Retamal JS, Klein-Cloud R, Bok D, Jensen DD, Gottesman-Katz L, Rientjes J, Veldhuis NA, Poole DP, Schmidt BL, Pothoulakis CH, Rankin C, Xie Y, Koon HW, Bunnett NW. Latorre R, et al. Among authors: veldhuis na. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2112059119. doi: 10.1073/pnas.2112059119. Proc Natl Acad Sci U S A. 2022. PMID: 35110404 Free PMC article.
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.
Poole DP, Amadesi S, Veldhuis NA, Abogadie FC, Lieu T, Darby W, Liedtke W, Lew MJ, McIntyre P, Bunnett NW. Poole DP, et al. Among authors: veldhuis na. J Biol Chem. 2013 Feb 22;288(8):5790-802. doi: 10.1074/jbc.M112.438184. Epub 2013 Jan 3. J Biol Chem. 2013. PMID: 23288842 Free PMC article.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW. Zhao P, et al. Among authors: veldhuis na. J Biol Chem. 2014 Sep 26;289(39):27215-27234. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. J Biol Chem. 2014. PMID: 25118282 Free PMC article.
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N. Cenac N, et al. Among authors: veldhuis na. Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22. Gastroenterology. 2015. PMID: 25911511
51 results